Background Macrophages are cells of the innate immune system that populate every organ. They are required not only for defense against invading pathogens and tissue repair but also for maintenance of tissue homeostasis and iron homeostasis. Aim The aim of this study is to understand whether heme oxygenase (HO) and nitric oxide synthase (NOS) contribute to the regulation of nicotinamide adenin...

Six La1-xSrxCoO3-δ (x= 0, 0.05, 0.15, 0.25, 0.35, 0.50) perovskites were synthesised and characterised by powder XRD and cyclic voltammetry on cone-shaped electrodes in either air or nitric oxide in argon at 200, 300 and 400C. At 200C the current densities in air was highest for the strontium free cobaltite, whereas the current densities was highest for La0.95Sr0.05CoO3-δ in the nitric oxide co...

Nitric oxide (NO) is involved in several biological processes, but its role in human melanogenesis is still not well understood. Exposure to UVA and UVB induces nitric oxide production in keratinocytes and melanocytes through the activation of constitutive nitric oxide synthase, increasing tyrosinase activity and melanin synthesis, whereas inducible nitric oxide synthase over expression might b...

nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. this study examined the effects of post-training intrahippocampal microinjections of 1400w as a selective inos inhibitor on spatial memory, in anesthetized and non-anesthetized situations in rats. in the present work, 4-day training trials of animals were conducted. spatial mem...

background: today, air pollution is one of the major problems in large cities including isfahan. methods: the objective of this study was to investigate the variations of ozone (o3), carbon monoxide (co), nitric oxide (no), nitrogen dioxide (no2), nitrogen oxides (nox), sulphur dioxide (so2), and particulate matter (pm10) concentrations in different months at three stations and also to explore ...

BACKGROUND Nitric oxide (NO) is a factor in cervical ripening, perhaps under the control of progesterone. We studied the effects of the antiprogesterone mifepristone on the release of NO and on the expression of inducible NO synthase (iNOS) and endothelial NO synthase (eNOS) in the uterine cervix of women in early pregnancy. METHODS Thirteen women were treated with oral mifepristone (200 mg),...

Effects of high concentrations of glucose on cell survival of differentiated PC12 cells were examined. Seven day-culture with D-glucose (9.0-27.0 mg/ml as 2-6-fold of the optimal level) induced cell death in a dose-related manner but 3-day culture with high concentrations of glucose had no effect on cell viability. L-glucose had no effect on viability of PC12 cells, suggesting that D-glucose to...

The identification of human inflammatory cells that express inducible nitric oxide synthase and the clarification of the role of inducible nitric oxide synthase in human infectious or inflammatory processes have been elusive. In neutrophil-enriched fractions from urine, we demonstrate a 43-fold increase in nitric oxide synthase activity in patients with urinary tract infections compared with th...

Asiatic acid is a triterpenoid isolated from Centella asiatica. The present study aimed to investigate whether asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (MS) induced by a high-carbohydrate, high-fat (HCHF) diet. Male Sprague-Dawley rats were fed with HCHF diet with 15% fructose in drinking water for 12 weeks to induce MS. MS rats were ...

BACKGROUND AND PURPOSE The present study was designed to examine the time course of nitric oxide (NO) production and the source of NO in the CA1 field of the gerbil hippocampus after transient forebrain ischemia. METHODS The production of NO in the CA1 field of the hippocampus after transient ischemia was monitored consecutively by measuring total NO metabolites (NOx-, NO2- plus NO3-) with th...