Glaucoma is a common progressive eye disorder and the treatment strategies will benefit from nanoparticulate delivery systems with high drug loading and sustained delivery of intraocular pressure lowering agents. Niosomes have been reported as a novel approach to improve drug low corneal penetration and bioavailability characteristics. Along with this, poor entrapment efficiency of hydrophilic ...

The present study was designed to develop and compare acyclovir containing nano-vesicular liposomes and niosomes based on cholesterol, soya L-alpha-lecithin and nonionic surfactant, span 20. The effort was made to study in vitro whether acyclovir-loaded nanovesicles could sustain the release of the drug by increasing residence time and thus, acyclovir could reduce its dose-related systemic toxi...

The aim of the present study was to prepare, optimize and characterize ketoprofen proniosomes. The niosomes were prepared using a slurry method followed by in vitro evaluation after embedding the proniosomes-derived niosomes into a carbopol matrix. A central, composite Box-Wilson design was used for the optimization with the total lipid concentration (X1), surfactant loading (X2) and amount of ...

At present days drugs are formulated by using different novel drug delivery system (NDDS) which are used for targeting drugs to different organ systems and for controlled /sustained release of drug from the dosage forms. The NDDS can be used to overcome many disadvantages of conventional dosage forms like poor bioavailability, first pass effect, systemic toxicity, degradation of drug in stomach...

Lacidipine (LAC) is a calcium channel blocker used in treatment of hypertension. In this study high performance liquid chromatography method (HPLC) is applied to the determination of LAC in rat plasma. The design of experiment used 3factor 3level Box Behnken Design for optimization of mobile phase condition. The effluent was monitored by UV detector at 240 nm, at a flow rate of 1.0 mL/min using...

BACKGROUND/AIM The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. MATERIALS AND METHODS Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for p...

Abstract Purposes Reactive oxygen species production is harmful to human’s health. The presence of antioxidants in the body may help diminish reactive species. Trans -ferulic acid a good antioxidant, but its low water solubility excludes utilization. study aims explore whether vesicular drug delivery could be way overcome poor absorption trans hence improving antimicrobial efficiency and antiox...