introduction: neuropathic pain may be due to a primary insult to the peripheral or central nervous system. in this situation, hyperalgesia and allodynia are the results of prostaglandins and cytokines release in the spinal cord. it seems that immune cells play an importat role in the induction and maintenance of chronic pain. compared to selective coxii inhibitors, nimesulide, a highly selectiv...

OBJECTIVE To estimate the risk of acute hepatotoxicity associated with nimesulide compared with other non-steroidal anti-inflammatory drugs. DESIGN Retrospective cohort and nested case-control study. SETTING Umbria region, Italy. PARTICIPANTS 400 000 current, recent, and past users (almost 2 million prescriptions) of non-steroidal anti-inflammatory drugs between 1 January 1997 and 31 Dece...

Nimesulide is a preferential cyclo-oxygenase-2 inhibitory non-steroidal anti-inflammatory drug has, infrequently, been associated with hepatic reactions. To establish the extent of formation of various metabolites (some of which might be hepato-reactive) the whole body metabolism, plasma kinetics and routes of excretion of the radio-labelled drug was undertaken in 4 fasted male volunteers follo...

The efficacy and tolerability profiles of nimesulide and diclofenac were evaluated in 180 patients suffering from various degenerative joint diseases. The clinical evaluations were performed at 0, 2 and 4 weeks. Nimesulide (100 mg) tablets were administered twice daily and diclofenac (50 mg) tablets were administered thrice daily. The principal efficacy parameters were the improvement in pain a...

Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was...

A series of Schiff’s bases i.e., N-(4-(benzylideneamino)-2-phenoxyphenyl)-4-methylbenzene-sulfonamide were synthesized from Nimesulide and studied for their in vivo anti-inflammatory activity. Hydrolysis of Nimesulide with sulphuric acid led to the formation 1 which on further reaction with benzene sulphonyl chloride yielded the title compounds 2. Compounds 2 reduced with tin in presence of con...

In this paper we describe new actions of nimesulide and paracetamol in cultured peripheral neurons isolated from rat dorsal root ganglia (DRG). Both drugs were able to decrease in a dose-dependent fashion the number of cultured DRG neurons showing translocation of protein kinase C epsilon (PKCɛ) caused by exposure to 1 μM bradykinin or 100 nM thrombin. In addition, the level of substance P (SP)...

OBJECTIVE To study the effect of nimesulide (4-nitro-2-phenoxymethane sulfonanilide) a non-steroidal anti-inflammatory drug, on antihistaminic activity of cetirizine. METHOD A randomized, double blind, cross over study was conducted in ten healthy male volunteers. Wheal and flare responses to histamine were measured by performing intradermal injection of histamine (2 micrograms base) diluted ...

BACKGROUND Nimesulide has been widely used to treat fever in children. Due to reports of adverse drug reactions, discontinuation or modification of its use has been suggested. OBJECTIVE To evaluate the safety of oral use of nimesulide in children. DESIGN Systematic review of published randomized controlled trials. SEARCH STRATEGY Electronic searches of databases (PubMed, Cochrane, Toxnet)...

Nimesulide, a widely used nonsteroidal anti-inflammatory drug containing a nitroaromatic moiety, has been associated with rare but serious hepatic adverse effects. The mechanisms underlying this idiosyncratic hepatotoxicity are unknown; however, both mitochondrial injury and oxidative stress have been implicated in contributing to liver injury in susceptible patients. The aim of this study was,...