OBJECTIVES This study was conducted to determine whether the blood pressure-lowering effect of Nigella sativa might be mediated by its effects on nitric oxide, angiotensin-converting enzyme, heme oxygenase and oxidative stress markers. METHODS Twenty-four adult male Sprague-Dawley rats were divided equally into 4 groups. One group served as the control (group 1), whereas the other three group...

We investigated the toxicity of the fixed oil of Nigella sativa L seeds in mice and rats through determination of LD50 values and examination of possible biochemical, hematological and histopathological changes. The acute toxicity of Nigella sativa fixed oil was investigated in mice. LD50 values, obtained by single doses, orally and intraperitoneally administered in mice, were 28.8 ml/kg body w...

Background and objectives: Nigella sativa is a delicate floral vegetable belonging to Ranunculaceae family. Thymoquinone (TQ) is the dominant active component in Nigella sativa seed oil which has a variety of pharmacological properties such as antioxidant, anticancer, anti-inflammatory and analgesic activities. However, TQ is a quinone derivative, which may le...

Nigella sativa (N. sativa) (Family Ranunculaceae) have been used for thousands of years as a curative remedy for various disorders. N. sativa seed reveal a broad spectrum of pharmacological activities including immunopotentiation and antihistaminic, antidiabetic, anti-hypertensive, anti-inflammatory, and antimicrobial activities. It is known as a source of thymoquinone, thymohydroquinone, dithy...

the anti-ischemic effect of aqueous and ethanolic extracts of nigella sativa l. seed was studied using a four-vessel occlusion model in rats. the ischemia was evaluated by optical and transmission electron microscopy. after 20 min of forebrain ischemia, agents were administered intraperitoneally after reperfusion. both extracts comprised an alkaloid. in ischemic rats, the aqueous (1 g/kg) and e...

background: several formulations of the nigella sativa l. seeds (black seed) have been used in traditional medicine for treatment and prevention of a wide range of diseases including diabetes. but blood glucose lowering effects of its oil in a clinical study is of an interest. objective: the present study was undertaken to explore the possible blood glucose lowering effects of the black seed oi...

BACKGROUND Since long high fat diet (HFD) is being blamed for causing fatty degeneration of liver and formation of atheromatous plaques. At present, no proper pharmacotherapy is available for both the conditions. In this study, different substances containing monounsaturated fatty acids were used to observe their protective effects in the HFD induced damage to liver and coronary vessels. OBJE...

Aim: To identify the anti-mutagenic effect of Nigella sativa on the experimentally induced chronic diabetes (type – II) in Wistar rats. Materials and Methods: The anti-mutagenic effect was evaluated in Nigella sativa treated diabetic rats against the streptozotocin nicotinamide (STZ-NA) (at a dose rate of 45-110 i.p mg/kg b.wt for 90 days) induced type-II diabetes mellitus using bone marrow mic...

Nigella sativa Linn. (Ranunculaceae) (N. sativa), commonly known as black seed or black cumin, is an herbaceous plant, mainly grows in the Middle East, Central Europe and Western Asia. It is widely used in indigenous system of medicine for treatment of numerous disorders for over 2 000 years[1-3]. Its seed oil had been widely used in Arab traditional of medicine for the treatment of arthritis, ...

background and aim: in most infections and diseases, to cure and decrease the effect of disease, induction and increasing power of immuno system are necessary. nigella sativa is a plant that has been used for treatment of many diseases. in this survey, the effect of nigella sativa is surveyed in strengthening of monocyte phagocytosis so that the use and mechanism of this plant for strengthening...