A hypothesis is presented suggesting that nicotinamide (NIC) is an initial signal substance in the response of eukaryotic cells to conditions which cause DNA-strand breakage, especially in connection with oxidative stress. In the stressed cell, NIC is released as a result of the activity of poly(ADP-ribose)polymerase (PADPRP). PADPRP is known to be activated by DNA-strand breakage, caused by e....

Endotoxin (Etx) causes excessive activation of the nuclear repair enzyme poly(ADP-ribose) synthase (PARS), which depletes cellular energy stores and leads to vascular dysfunction. We hypothesized that PARS inhibition would attenuate injury to mechanisms of pulmonary vasorelaxation in acute lung injury. The purpose of this study was to determine the effect of in vivo PARS inhibition on Etx-induc...

Nicardipine hydrochloride (Nic), a calcium channel antagonist, is used for the treatment of hypertension. In the present study, we estimated its effects on the levels and activities of hepatic cytochrome P450 isoforms in spontaneously hypertensive rats given p.o. with Nic at a dose of 0.5, 2.5, 5, or 12.5 mg/kg at 24-hr intervals for 14 days. Therapeutic effects on the development of hypertensi...

A graph is NIC-planar if it admits a drawing in the plane with at most one crossing per edge and such that two pairs of crossing edges share at most one common end vertex. NIC-planarity generalizes IC-planarity, which allows a vertex to be incident to at most one crossing edge, and specializes 1-planarity, which only requires at most one crossing per edge. We characterize embeddings of maximal ...

The transition of the Network Information Center from SRI International in Menlo Park, CA, to Government Systems Inc. in Chantilly, VA, is officially scheduled for 1 October 1991. This includes the transition of services currently offered to DDN and Internet users by SRI. These services include network/user registration (i.e., network number and top level domain name assignment), on-line inform...

One hundred twenty nine accession of sesame with susceptible (TC-25) and resistance check (SI-250) were screened under natural infestation condition during two consecutive seasons 2019 2020 to identify the source against leaf roller capsule borer (Antigastra catalaunalis Dup.) at AICRP on oilseeds center JNKVV, College Agriculture, Tikamgarh (M.P.). The categorized as highly resistant (HR), (R)...

Receive-side scaling (RSS) is a technique that stores the arriving IP packets in the same flow into the same hardware queue of a modern network interface card (NIC). It allows scalable processing of the received packets by allowing exclusive access to the NIC queues by each CPU core. This removes the lock contention when accessing the NIC queue, and it allows concurrent access to different queu...

An efficient barrier implementation is desirable on parallel systems to obtain good parallel speedup and to support finer-grained computation. Some modern Network Interface Cards (NICs) have programmable processors which can be used to provide support for collective communications such as barrier. In this paper, we utilize such a programmable NIC to provide an efficient barrier synchronization ...

Functional recovery does not occur in 10% of patients with neonatal brachial plexus palsy. In these patients, resection of a neuroma-in-continuity (NIC) and surgical nerve reconstruction are required. The formation of a NIC seems to prohibit functional recovery, but the underlying biologic mechanisms for this failure are poorly understood. We systematically analyzed a large series of NIC tissue...

In this paper we present an architectural concept for network interface cards (NIC) targeting embedded systems and supporting I/O virtualization. Current solutions for high performance computing do not sufficiently address embedded system requirements i.e., guarantee real-time constraints and differentiated service levels as well as only utilize limited HW resources. The central ideas of our wo...