1287 Patients with a history of heart disease are at increased risk for future cardiovascular events, including myocardial infarction (MI), stroke, and death resulting from cardiovascular disease. Although coronary artery disease remains the leading cause of mortality worldwide, advancements in medical therapy, particularly antithrombotic agents, have improved patient outcomes. Although the tre...

1648 Abstract—Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the regulation of cholesterol homeostasis. By binding to hepatic low-density lipoprotein (LDL) receptors and promoting their lysosomal degradation, PCSK9 reduces LDL uptake, leading to an increase in LDL cholesterol concentrations. Gain-of-function mutations in PCSK9 associated with high LDL cholester...

Non-invasive neural stimulation techniques are of increasing importance as devices move from the lab to the clinical environment. One such technology-transcranial magnetic stimulation-has already made the transition and is currently used by clinicians to treat depression. This device has several drawbacks, such as a limited ability to focus its energy to a relatively small region and to distrib...