PURPOSE The objectives of the analysis were to characterize the time course of neutropenia after pemetrexed administration using an established semimechanistic-physiologic model, characterize the relationship between pemetrexed exposure and neutropenia, and describe differences in neutropenic response by vitamin supplementation status and between Japanese and Western patients. EXPERIMENTAL DE...

OBJECTIVES Granulocyte colony-stimulating factor (G-CSF) stimulates proliferation of neutrophils and enhances their phagocytic and microcidal activity. Increasing resistance to existing antibacterials and the dearth of new alternatives have complicated the treatment of Gram-negative infections. The aim of this study was to evaluate the efficacy of G-CSF in the treatment of Pseudomonas aeruginos...

BACKGROUND Immunocompromised patients who develop sepsis while neutropenic are at high risk for morbidity and mortality; however, it is unknown if neutropenic sepsis is associated with distinct clinical and biological characteristics. METHODS We conducted a prospective cohort study of patients admitted to the medical intensive care unit of an academic medical center with severe sepsis. Patien...

background: systemic candidiasis is a major complication in neutropenic cancer patients undergoing treatment. most systemic fungal infections emerge from endogenous microflora so the aim of the present study was to identify candida species isolated from the different regions of body   in neutropenic patients in compare with the control group. methods: a total of 309 neutropenic cancer patients ...

Neutropenic complications remain an important dose-limiting toxicity of cancer chemotherapy-associated with considerable morbidity, mortality, and cost. Risk of the initial neutropenic event is greatest during the first cycle. The purpose of this study was to better understand timing of neutropenic events in relation to delivered chemotherapy dose intensity and utilization of supportive care du...

Division of Clinical Sciences, Paediatric Infectious Diseases Research Group, St. George’s, University of London, London, UK Department of Paediatric Oncology, Great Ormond Street Hospital NHS Foundation Trust, London, UK London South Bank University, London, UK Oncology Unit, Royal Hospital for Sick Children, Edinburgh, UK Oncology Unit, Alder Hey Childrens NHS Foundation Trust, Liverpool, UK ...

A progressive increase in infections with multiresistant Enterococcus faecium has been reported, especially in cancer patients and neutropenic patients. Despite its increasing importance as a nosocomial pathogen, knowledge of the pathogenesis of E. faecium infections is highly limited. In this study, we investigated the role of neutrophils during peritonitis with subsequent bacteremia caused by...

Background. Invasive fungal infections (IFI) are a significant source of morbidity and mortality in neutropenic patients. Risk based prophylaxis or pre-emptive therapy are debated clinical approaches. Since 2009, IPC at our tertiary care institution has collected the IFI rate per 1,000 neutropenic patient days. We examine IFI per neutropenic episode by patient characterictics and duration of ne...