Physically active lifestyles have become increasingly rare in developed countries, while endurance and neuromuscular performance have declined and the prevalence of overweight among children and youth has increased in recent decades. Sedentary lifestyles may not only be associated with increased cardiometabolic risk but also less optimal circumstances for cognitive development and academic achi...

neuromuscular diseases are abnormal processes involving cns (central nervous system), pns (peripheral nervous system), nmj (neuromuscular junction), muscle or any combination of these. our goals in neuromuscular disease are maintenance of function, quality of life, educate patient and family, anticipate needs, expect change and prevent or delay complications. limb contractures and scoliosis, we...

hereditary inclusion body myopathy (hibm) is an adult-onset hereditary myopathy, usually with distal onset and quadriceps sparing. this myopathy is autosomal recessive and associated to upd-n-acetylglucosamine-2-epimerase/n-acetylmannosamine kinase (gne) gene mutations. in this study, we report a novel gne homozygous point mutation c.1834t>g that results in amino acid substitution of cysteine 6...

objective neuromuscular disorders (diseases of the motor unit), can cause respiratory problems such as impaired cough reflex, chest deformity, recurrent pneumonia and acute respiratory failure; these are the worst most common complications of these diseases and the leading cause of death in such patients (1, 2). their management hence, very often, entails admission to the pediatric intensive ca...

OBJECTIVE: To discuss the most important aspects for the performance of a differential diagnosis among the main neuromuscular disorders in children, which include diseases affecting the motor unity, i.e. spinal motor neurons, peripheral nerves, neuromuscular junction and muscular fibers. SOURCES: The review of the clinical aspects that should be considered for a prompt differential diagnosis am...

BACKGROUND Transcranial direct current stimulation (tDCS) has been used to enhance endurance performance but its precise mechanisms and effects remain unknown. OBJECTIVE To investigate the effect of bilateral tDCS on neuromuscular function and performance during a cycling time to task failure (TTF) test. METHODS Twelve participants in randomized order received a placebo tDCS (SHAM) or real ...