نتایج جستجو برای: neuromelanin nm
تعداد نتایج: 126090 فیلتر نتایج به سال:
The loss of dopaminergic (DA) neurons in the substantia nigra (SN) is a major pathophysiological feature of patients with Parkinson's disease (PD). As nigral DA neurons contain both neuromelanin (NM) and dopamine transporter (DAT), decreased intensities in both NM-sensitive MRI and DAT PET reflect decreased DA neuronal density. This study demonstrates that a more specific metric for the nigral ...
Recent data indicates that prolonged bright light exposure of rats induces production of neuromelanin and reduction of tyrosine hydroxylase positive neurons in the substantia nigra. This effect was the result of direct light reaching the substantia nigra and not due to alteration of circadian rhythms. Here, we measured the spectrum of light reaching the substantia nigra in rats and analysed the...
OBJECTIVES We investigated the locus coeruleus complex in the brainstems of 78 subjects aged from 24 gestational weeks to 8 postnatal months, who died of unknown (sudden unexplained fetal and infant deaths) and known causes (controls). The goals of this study were: (1) to obtain basic information about the morphology of the locus coeruleus complex and the expression of different biological par...
This publication proposes a computer-based platform to explore novel targets for symptomatic treatment, based on the known neuroanatomy and neurophysiology of the basal ganglia (Roberts et al., 2016). However, this theoretical proposal should also take into consideration other aspects, such as the possible molecule(s) involved in the loss of dopaminergic neurons containing neuromelanin, because...
In this study, a comparative analysis of metal-related neuronal vulnerability was performed in two brainstem nuclei, the locus coeruleus (LC) and substantia nigra (SN), known targets of the etiological noxae in Parkinson's disease and related disorders. LC and SN pars compacta neurons both degenerate in Parkinson's disease and other Parkinsonisms; however, LC neurons are comparatively less affe...
Three females in their fifties and five males in their seventies, all of whom had been exposed to the Nagasaki atomic bomb explosion in 1945, were investigated concerning the aging of neurons of the dorsal root ganglia. Through this study dealing with the frequency of neurons with intracytoplasmic pigments, lipofuscin, neuromelanin, eosinophilic granules and neurons free of pigment, no signific...
Diagnosis and monitoring of diseases by measurement of biochemical markers has most commonly been performed on samples of peripheral blood. However, no such markers are available for clinical use in the major diseases of the central nervous system (CNS). In Parkinson’s disease circulating biomarkers would find clinical utility in early diagnosis and also monitoring of disease progression. Of pa...
Recent in situ three-dimensional structural studies have provided a new model for the 30 nm chromatin fiber. In addition, research during the past year has revealed some of the molecular complexity of non-histone chromosomal proteins. Still to come is the unification of molecular insights with chromosomal architecture.
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