Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...

objective: this study was designed to examine the effects of human umbilical cord matrix stemcell (hucmsc) administration in rats for 6 week after traumatic brain injury (tbi). materials and methods: adult male wistar rats (n = 30) were injured with controlled cortical impact device and divided into three groups. the treatment groups (n = 10 each) were injected with 2 × 106 (2 milion) intraveno...

cortical spreading depression (csd) has been suggested to underlie some neurological disorders such as migraine. despite the intensity with which many investigators have studied sd in the brain, only a few studies have aimed to identify sd in the spinal cord. here we described the main characteristic features of sd in the spinal cord induced by different methods including various spinal cord in...

acute injuries of the spine and spinal cord are among the most causes of severe disability and death after trauma. data about spine fracture with or without cord damage are different. the aim of this study was to determine epidemiology and demographics of spinal injury in main trauma center, guilan, an iranian province. the present study was a descriptive study of all cases of traumatic spine i...

Marcalee Sipski Alexander, MD Spinal cord injury remains a disorder without a sufficient remedy. Although both private and academic researchers continue to pursue therapies, proof of efficacy in improving neurological recovery remains elusive. One of the reasons for this difficulty may be our lack of sensitive outcome measures related to neurological and functional recovery after spinal cord in...

Abstract Background Mindfulness has demonstrated strong utility for enhancing self-management and health outcomes in chronic illness. However, sensation-focused mindfulness techniques may not be appropriate clinical populations with neurological injury. This study aimed to identify how expert teachers sensory loss/impairment naturalistically adapt experience mindfulness. We highlight the ration...