نتایج جستجو برای: neurofibrillary tangles
تعداد نتایج: 3487 فیلتر نتایج به سال:
Alzheimer’s disease (AD) is the most common neurodegenerative disease, which characterized by deposition of senile plaques composed amyloid-β (Aβ) and neurofibrillary tangles (NFTs) hyperphosphorylated tau. Currently, underlying cellular molecular mechanisms AD are still unclear. Growing evidence suggests that pathogen infections prominently promote development pathology. In this article, we re...
Neurofibrillary degeneration induced by misfolded protein tau is considered to be one of the key pathological hallmarks of Alzheimer's disease (AD). In the present study, we have introduced a novel transgenic rat model expressing a human truncated tau that encompasses 3 microtubule binding domains (3R) and a proline-rich region (3R tau151-391). The transgenic rats developed progressive age-depe...
A quantitative study has been made of the number of neurofibrillary tangles and of the choline acetyltransferase activity in several sites in the cerebral hemispheres of eight patients who had had Alzheimer's disease. The neurofibrillary tangles were maximal in structures in the medial temporal lobe (uncus, amygdala, hippocampus and parahippocampal gyrus), severe in the neocortex on the lateral...
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