Germ cell tumors account for less than 3% of all ovarian cancers. These tumors generally appear in childhood or in those under 30 years of age. Immature ovarian teratoma is the third most frequent germ cell tumor after dysgerminoma and endodermal sinus tumors. These tumors should be distinguished from mature teratomas. Discrimination of malignant and benign tumors depends on the presence of the...

Accurate diagnosis of primitive childhood sarcomas continues to be a formidable problem because these malignancies generally demonstrate very little morphological evidence of their tissue of origin. One of these tumor classes, the Ewing's sarcoma family of peripheral primitive neuroectodermal tumors (pPNETs), are thought to have a neural histogenesis based on evidence of neuroectodermal differe...

Accurate diagnosis of primitive childhood sarcomas continues to be a formidable problem because these malignancies generally demonstrate very little morphological evidence of their tissue of origin. One of these tumor classes, the Ewing's sarcoma family of peripheral primitive neuroectodermal tumors (pPNETs), are thought to have a neural histogenesis based on evidence of neuroectodermal differe...

Immunohistochemical staining intensity for ganglioside GD1b was determined for 108 human neuroectodermal tumors. Most of the tissue elements that immunostained were tumor cells; only a few axons and occasional neurons reacted in some specimens. All pilocytic astrocytomas stained very positively, whereas none of the ependymomas and only 11% of primitive neuroectodermal tumors, 20% of glioblastom...

Expression of insulin-like growth factor I (IGF-I) mRNA by some tumor cell lines of neuroectodermal origin has been described. To further explore the significance of IGF-I mRNA expression in these tumors, a more extensive analysis was performed. Most (9 of 10) neuroectodermal tumor cell lines with a t(11;22) translocation (primitive neuroectodermal tumor IPNETI, Ewing's sarcoma, esthesioneurobl...

Two cases of melanotic neuroectodermal tumour of infancy (MNTI), otherwise known as melanotic progonoma, both arising from the maxilla are presented here. The two infants both presented within three months of each other and though clinically Burkitt's lymphoma was stated as a possible diagnosis, the correct diagnosis was made on biopsy specimens. Radical surgery consisting of wide resection of ...

Testicular cancer accounts for ∼1% of all cancers in men worldwide, with over 90% testicular being germ cell tumors (GCTs). Since the introduction multimodal therapy, GCTs have been among most curable solid tumors. However, some patients may develop late relapse, which is defined as recurrence at least two years after initial complete remission. Late particularly common teratomatous and associa...

We present a case series of five patients who were diagnosed in our institution with rare tumors of neuroectodermal origin. They were discovered within 1 year, by two otorhinolaryngologists at the county hospital which covers the area of about 1,00,000 inhabitants. Neuroectodermal tumors of the head and neck are rare pathologies, with extremely varied clinical behavior, treatment and prognosis....

We have investigated the expression of the dbl protooncogene in a wide variety of human tumors of different embryological derivation. We found that proto-dbl mRNA could be detected preferentially in a few neoplastic histiotypes of neuroectodermal origin. The common, normal 5-kilobase size of the proto-dbl transcript detected indicated that the proto-dbl in these tumors was not rearranged. These...