brain injury is a complex event leading to tissue damage and functional deficits by primary and secondary mechanisms. since the application of tissue engineering approaches is a new topic in the treatment of brain injury, producing a proper experimental model to evaluate the effects of tissue engineering products on damaged brain tissue is required. in the present study, a simple and reproducib...

objective (s): the scarcity of articular cartilage defect to repair due to absence of blood vessels and tissue engineering is one of the promising approaches for cartilage regeneration. the objective of this study was to prepare an extracellular matrix derived decellularized bovine articular cartilage scaffold and investigate its interactions with seeded rat bone marrow mesenchymal stem cells (...

background dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. the chondrocyte is surrounded by a pericellular matrix (pcm), together forming the chondron. pcm has a positive effect on the maintenance of chondrocyte phenotype during culture in compariso...

background: the aim of this study was to fabricate the poly caprolactone (pcl) aligned nanofiber scaffold and to evaluate the survival, adhesion, proliferation, and differentiation of rat hair follicle stem cells (hfsc) in the graft material using electrospun pcl nanofiber scaffold for tissue engineering applications. methods: the bulge region of rat whisker was isolated and cultured in dmem: n...

spinal cord injury (sci) results in the damage of motor and sensory pathways. the molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. regeneration of injured central nervous system (cns) is limited by damaged cell environment. biomaterial scaffolds can reconstruct injured cns tissue following sci by promoting the migratio...

please cite this article as : tavakoli-darestani r, kazemian gh, emami m, kamrani-rad a. poly (lactide-co-glycolide) nanofibers coated with collagen and nano-hydroxyapatite for bone tissue engineering. novel biomed 2013;1:8-15. background: a combination of polymeric nanofibrous scaffold and bioactive materials is potentially useful in bone regeneration applications. materials and methods: in th...

cartilage is an avascular, aneural, and alymphatic connective tissue with a limited capacity caused by low mitotic activity of its resident cells, chondrocytes. natural repair of full thickness cartilage defects usually leads to the formation of fibrocartilage with lower function and mechanical force compared with the original hyaline cartilage and further deterioration can occur. tissue engine...

background: engineering new bone tissue with cells and a synthetic extracellular matrix represents a new approach for the regeneration of mineralized tissues compared with the transplantation of bone (autografts or allografts). methods: in this study, to mimic the mineral and organic component of natural bone, hydroxapatite (ha) and gelatin (gel) composite scaffolds were prepared. the raw mater...