one of the main problems following road accidents is brain injury after which death and disability in the most active population occurs. considering the fact that there is no definite clinical treatment for repair of damaged brain tissue, the present study examined the effects of autologous adult neural stem/progenitor cells (ns/pcs) seeded in a nanoscaffold named puramatrix in acute brain inju...

neural stem cells (nscs) as a heterogeneous multipotent and self- renewal population are found in different areas in the developing mammalian nervous system, as well as the sub-ventricular zone (svz) and the hippocampus of the adult brain. nscs can give rise to neurons, astrocytes and oligodendrocytes. the aim of this study was to differentiate neural stem cells into noradrenergic–like cells in...

spinal cord injury (sci) is a destructive condition that the cord can't send signals below the level of the injury. despite advances in the medical and surgical care of sci patients, no effective treatment exists for the neurological deficits of sci. cell therapy is a new approach for sci, and preclinical models demonstrate that cell transplantation can improve some secondary events throug...

The earliest murine neural stem cells are leukemia inhibitory factor (LIF)-dependent, primitive neural stem cells, which can be isolated from embryonic stem cells or early embryos. These primitive neural stem cells have the ability to differentiate to non-neural tissues and transition into FGF2-dependent, definitive neural stem cells between embryonic day 7.5 and 8.5 in vivo, accompanied by a d...

objective(s): scutellarin, a flavonoid extracted from the medicinal herb erigeron breviscapus hand-mazz, protects neurons from damage and inhibits glial activation. here we examined whether scutellarin may also protect neurons from hypoxia-induced damage. materials and methods: mice were exposed to hypoxia for 7 days and then administered scutellarin (50 mg/kg/d) or vehicle for 30 days cognitiv...

multiple sclerosis (ms) is an autoimmune inflammatory demyelinating disease of the central nervous system. the aim of this study was to investigate the neuroprotective effects of transplanted human umbilical cord blood mesenchymal stromal cells (ucb-msc) derived neural progenitor cell (mdnpc) in eae, an experimental model of ms. to initiate neuronal differentiation of ucb-mscs, the pre-inductio...

background: transplants of multipotent stem cells have been shown to have a neuroprotective effect after central nervous system injury. the bulge region of the hair follicle has been reported as a putative source of hair follicle stem cells (hfsc) for many years; however, few studies have documented the properties of bulge derived cells in vitro until now. this study was conducted to isolate an...

introduction: the native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. considering the suitable characteristics of induced pluripotent stem cells (ipscs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (de...

objective(s): in the past few decades, variety of foetal, embryonic and adult stem and progenitor cells have been tried with conflicting outcome for cell therapy of central nervous system injury and diseases. cellular characteristics and functional plasticity of globose basal stem cells (gbcs) residing in the olfactory epithelium of rat olfactory mucosa have not been studied in the past by the ...