Despite advances in surgical techniques for peripheral nerve repair, functional restitution remains incomplete. The timing of surgery is one factor influencing the extent of recovery but it is not yet clearly defined how long a delay may be tolerated before repair becomes futile. In this study, rats underwent sciatic nerve transection before immediate (0) or 1, 3, or 6 months delayed repair wit...

peripheral nerve injuries (pni) can lead to lifetime loss of function and disfigurement. different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. utilization of absorbable and non-absorb...

objective(s) motor deficit and neuron degeneration is seen after nerve transection. the aim of this study is to determine whether a poled polyvinelidene fluoride (pvdf) tube with other supportive strategies can protect the neuronal morphology and motor function after sciatic nerve transaction in rats. materials and methods after transection of the left sciatic nerve in 60 male wistar rats (200-...

Neurotrauma injuries are notoriously difficult to deal with both clinically as well experimentally, the cellular and molecular events ensuing after injury complicate neuroinflammatory processes. Spinal cord further complicated by formation of scars at sites, which can provide a physical barrier repair. The lack effective clinical therapy for spinal underscores need experimental approaches gener...

abstract   background : although, different studies on end-to-side nerve repair, results are controversial. the importance of this method in case is unavailability of proximal nerve. in this method, donor nerves also remain intact and without injury. in compare to other classic procedures, end-to-side repair is not much time consuming and needs less dissection. overall, the previous studies in ...

Currently a wide variety of polymer materials are being applied to fabricate nerve guide tubes to repair injured peripheral nerves. In this study we have examined whether collagen-chitosan nerve guides promotes nerve repair compared to chitosan nerve guides using histological analysis. Results indicates that the enclosed structure of the nerve guide both promotes and supports axonal sprouting. ...

Peripheral Nerve Injuries are one of the most common causes of hand dysfunction caused by upper limb trauma but still current management has remained suboptimal. This review aims to explain the traditional view of pathophysiology of nerve repair and also describe why surgical management is still inadequate in using the new biological research that has documented the changes that occur after the...