BACKGROUND Previous designs of internal bone lengthening devices have been fraught with imprecise distraction, resulting in nerve injuries, joint contractures, nonunions, and other complications. Recently, a magnet-operated PRECICE nail (Ellipse Technologies, Inc, Irvine, CA, USA) was approved by the FDA; however, its clinical efficacy is unknown. QUESTIONS/PURPOSES We evaluated this nail in ...

Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. Recently, it has been shown that aucubin prevents neuronal death in the hippocampal CA1 region in rats with diabetic encephalopathy. In addition, it has protective effects on H2O2-induced apoptosis in PC12 cells. We have shown he...

Movements generated by muscle contraction generally include periods of muscle shortening and lengthening as well as force development in the absence of external length changes (isometric). However, in the specific case of resistance exercise training, exercises are often intentionally designed to emphasize one of these modes. The purpose of the present study was to objectively evaluate the rela...

BACKGROUND Nerve palsy is a potentially devastating complication following total hip arthroplasty. The purpose of this study was to retrospectively identify risk factors for, and the prognosis associated with, a motor nerve palsy following primary total hip arthroplasty. METHODS Between 1970 and 2000, 27,004 primary total hip arthroplasties were performed at our institution. Forty-seven patie...

Humans and non-human primates are known to lengthen their response time (RT) to a go signal when they occasionally must cancel their responses following a stop signal in a countermanding task as well as to adjust their RT adaptively on a trial-by-trial basis. Less is clear regarding the adaptive RT adjustments in the countermanding performance of rodents. To investigate this question, male Wist...

Ilizarov is an accepted technique for lengthening short amputation stumps to improve prosthetic function andrehabilitation. The relation of stump lengthening and phantom limb pain (PLP) has not been reported in literature.We present here a case report of a transfemoral amputee who had a flare up of PLP following stump lengthening.He responded well to a combination of pharmacological therapy and...

This is an audit of complications resulting from correction of complex lower limb deformities by the Ilizarov technique. 33 patients (40 bone segments) were reviewed and divided into 4 groups according to the type of surgery carried out: limb lengthening and/or correction of deformity, bone or joint stabilisation, treatment of nonunion or bone defect, angular and/ or rotation correction. Most m...

Achieving frontal plane alignment of the ankle joint during primary and revision total ankle replacement is essential for long-term success. This manuscript presents the revision of a failed AgilityTM LP total ankle replacement system with severe > 40° varus ankle deformity that was corrected with explanation and conversion to an INBONETM II total ankle system coupled with soft-tissue release/r...

Introduction: Femoral/tibial lengthening with a telescopic, magnetically-powered, intramedullary nail is an alternative to lengthening with external fixation. Methods: Pre-clinical testing was conducted of the PRECICE in a human cadaver. A retrospective review of the first 30 consecutive patients who underwent unilateral lengthening was also conducted. Nail accuracy was obtained by comparing th...