Introduction: Prior qualitative and quantitative studies have reported morphological changes that occur in nerve fibers and non-neuronal cells of peripheral nerve during the lifetime of the rats. Previous studies suggest that Aloe Vera has some beneficial and therapeutic effects such as anti-oxidant effects. In the current study, we have evaluated histological and histomorphometric changes of Sc...

An in vitro preparation of rabbit cornea was used to compare anatomical specialization and electrophysiological responses of A delta and C fiber sensory afferents which terminate as free nerve endings. Living nerve endings were visualized using epifluorescence microscopy and the vital dye 4-di2-ASP, and response properties were determined using microstimulation and recording of fiber discharge ...

INTRODUCTION Small fiber neuropathy might be a part of typical mixed small and large fiber neuropathy, or a distinct entity, affecting exclusively small nerve fibers. OBJECTIVES Explore the utility of small nerve fiber testing in patients with clinical presentation suggesting small fiber neuropathy, with and without evidence for concomitant large fiber neuropathy. METHODS Patients attending...

PURPOSE To assess the effects of topiramate on C-fiber function, nerve fiber morphology, and metabolism (including insulin sensitivity, obesity, and dyslipidemia) in type 2 diabetes. PATIENTS AND METHODS We conducted an 18-week, open-label trial treating patients with topiramate. Twenty subjects with type 2 diabetes and neuropathy (61.5 ± 1.29 years; 15 male, 5 female) were enrolled and compl...

PURPOSES To evaluate the retina nerve fiber layer by laser polarimetry in patients in chronic use of chloroquine. METHODS Forty-four eyes of twenty-two patients were studied. These were in use of chloroquine due to rheumatic diseases during at least one year. As a control group, twenty patients without use of chloroquine with similar characteristics (age, gender and race) were included. Patie...

PURPOSE The aim of this study was to quantify epithelial, stromal, and endothelial cell density, and subbasal nerve morphology in young patients with type 1 diabetes mellitus with and without diabetic retinopathy. METHODS A total of 28 young patients (mean age, 22.86 ± 9.05 years) with type 1 diabetes, with (n = 18) and without (n = 10) retinopathy, and 17 age-matched healthy control subjects...

BACKGROUND Skin denervation in vasculitic neuropathy has rarely been documented despite frequent manifestations of small-fiber neuropathy including reduced sensitivity and neuropathic pain. Recently, skin biopsy has been established as a new approach to diagnose small-fiber sensory neuropathy. OBJECTIVES To investigate the pathologic features of cutaneous nerves and to evaluate inflammatory v...

Surrogate markers of diabetic neuropathy are being actively sought to facilitate the diagnosis, measure the progression, and assess the benefits of therapeutic intervention in patients with diabetic neuropathy. We have quantified small nerve fiber pathological changes using the technique of intraepidermal nerve fiber (IENF) assessment and the novel in vivo technique of corneal confocal microsco...

purpose: to compare peripapillary retinal nerve fiber layer (rnfl) thickness among multiple sclerosis (ms) patients with or without a history of optic neuritis (on) and a healthy control group. methods: in this retrospective case-control study, 59 ms patients were recruited from a neurology clinic of imam hossein hospital. of which, 36 patients had at least one episode of on and 23 others had n...

regeneration and engineering of functional new tissues containing the neural network have great importance. progression of neural network into the dental tissue has a crucial role in dental tissue regeneration. in the present study polymer-ceramic blended scaffolds containing different weight percentages of carbon nanotube in poly caprolactone nanofiber matrix were fabricated. morphological, me...