Named entity recognition (NER) is a fundamental task in natural language processing. In Chinese NER, additional resources such as lexicons, syntactic features and knowledge graphs are usually introduced to improve the performance of model. However, characters evolved from pictographs, their glyphs contain rich semantic information, which often ignored. Therefore, order make full use information...

Named Entity Recognition (NER) is an important task in knowledge extraction, which targets extracting structural information from unstructured text. To fully employ the prior-knowledge of pre-trained language models, some research works formulate NER into machine reading comprehension form (MRC-form) to enhance their model generalization capability commonsense knowledge. However, this transform...

In mammalian cells, mRNA transcription is initiated with the aid of transcription initiation factors. Of these, TFIIH has also been shown to play an essential role in nucleotide excision repair (NER), which is a versatile biochemical pathway that corrects a broad range of DNA damage. Since the dual role of TFIIH is conserved among eukaryotes, including yeast and mammalian cells, the sharing of ...

Both clinical and experimental evidence illustrate that p190 and p210 BCR/ABL oncogenic tyrosine kinases induce resistance to DNA damage and confer an intrinsic genetic instability. Here, we investigated whether BCR/ABL expression could modulate nucleotide excision repair (NER). We found that ectopic expression of p210 BCR/ABL in murine lymphoid BaF3 cell line inhibited NER activity in vitro, p...

Several proteins, including Rad3 and Rad25(Ssl2), are essential for nucleotide excision repair (NER) and function in the RNA polymerase II transcription initiation complex TFIIH. Mutations in genes encoding two other subunits of TFIIH, TFB1 and SSL1, result in UV sensitivity and have been shown to take part in NER in an in vitro system. However, a deficiency in global NER does not exclude the p...

RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TC-NER), a specific sub-pathway of nucleotide excision repair. To improve our knowledge of transcription elongation and its coupling to TC-NER, ...

Chemical named-entity recognition (chemical NER) is the task of extracting chemical information and chemical-related entities such as drug names and source materials from text in several domains such as bioinformatics and nanoinformatics. There have been several attempts to construct corpora for handling such chemical-related information based on different corpus-construction guidelines. Even t...

NER in microposts is a key and challenging task of mining semantics from social media. Our evaluation of a number of popular NE recognizers over a micropost dataset has shown a significant drop-off in results quality. Current state-of-theart NER methods perform much better on formal text than on microposts. However, the experiment provided us with an interesting observation – although individua...

Nucleotide excision repair (NER) is universally used to recognize and remove many types of DNA damage. In eubacteria, the NER system typically consists of UvrA, UvrB, UvrC, the UvrD helicase, DNA polymerase I, and ligase. In addition, when DNA damage blocks transcription, transcription-repair coupling factor (TRCF), the product of the mfd gene, recruits the Uvr complex to repair the damage. Pre...

Chronic pulmonary inflammation is associated with increased lung cancer risk, but the underlying process remains unknown. Recently, we showed that activated neutrophils inhibit nucleotide excision repair (NER) in pulmonary epithelial cells in vitro via the release of myeloperoxidase (MPO). To evaluate the effect of neutrophils on NER in vivo, mice were intratracheally instilled with lipopolysac...