During the past two years 16 cases of nephrosis have been treated with cortisone and/or A.C.T.H. (adrenocorticotrophin) at this hospital. The results of cortisone treatment have been reported previously (Arneil and Wilson, 1952) and corresponding findings for A.C.T.H. are now given and the value of the two hormones compared. The criteria used when including a patient in this investigation and t...

A 63-YR-OLD male (weighing approximately 83 kg) with no significant past medical history underwent an open reduction and internal fixation of his femur fracture under general anesthesia. He had been nil per os for 14 h and his preoperative blood pressure was 136/74 mmHg. Intraoperative course was uneventful, except for a 5–7 min episode of relative hypotension with systolic pressures 80 – 85 mm...

The accepted picture of the nephrotic syndrome is that of a grossly oedematous patient with massive albuminuria but having no hypertension or azotaemia. The amount of albumin circulating in the plasma is greatly reduced, resulting in a fall in the total protein content and a reversal of the albumin/ globulin ratio. The cholesterol content of the blood is markedly raised. Little is known of the ...

Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the sh...

OBJECTIVES To clarify the causes of death of residents with renal tubular dysfunction induced by cadmium (Cd) in the environment. METHODS A 15 year follow up study was performed with the inhabitants living in the Cd polluted Kakehashi River basin in Japan. Standardised mortality ratios (SMRs) for causes of death, classified by ICD-9, were computed using the person-years method to investigate ...