Human pathological conditions of the central nervous system (CNS) associated with angiogenesis (i.e. neovascularization) include neoplastic, as well as infectious, ischemic, and traumatic processes. Upregulation of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) and tenascin-C (TN-C) is spatially and temporally related to neovascularization. Spatially, VEGF/VPF and TN...

Both diminution of angiostatic and increment of angiogenic factors seem to contribute to neovascularization in the eye under pathologic conditions. They are presented here separately. The involved proteins can change their role during the process of neovascularization from promoters to inhibitors and vice versa. Angiostatic factors can be divided into passive, active, unspecific and specific on...

Timolol is a non-selective beta-adrenergic antagonist that is similar to propranolol. The mechanism through which these drugs act on the regression of neovascularization is largely unknown. However, it is thought that the drugs may act through vascular endothelial growth factor signaling, vasoconstriction, and vascular endothelial cell apoptosis. The aim of this study was to determine the effec...

PURPOSE Neovascularization of the avascular cornea is a significant problem associated with many corneal diseases. Because Fas ligand (FasL) is highly expressed in the cornea, the role of this molecule in controlling corneal neovascularization was examined in this study. METHODS C57BL/6(B6), FasL (CD95L)-deficient B6-gld, and Fas (CD95)-deficient B6-lpr mice were subjected to the suture model...

The aim of this study is to elucidate the association of neovascularization in branch retinal vein occlusion (BRVO) combined with major arterial insufficiency (MAI), compared with BRVO alone. The authors retrospectively reviewed the charts, color photographs, and fluorescein angiograms of 304 patients (308 eyes) who had BRVO from 1990 to 2002 at Hanyang University hospital. Patients with BRVO c...

BACKGROUND To report the rare occurrence of peripheral retinal sea-fan neovascularization in a patient with chronic rhegmatogenous retinal detachment and describe the surgical management. CASE PRESENTATION A 29-year-old female patient was referred to our department by her ophthalmologist for investigation and treatment of peripheral retinal neovascularization in her right eye(RE). Visual acui...

Dr. Ashish Vaidya Vitreo-retinal Consultant, Bombay City Eye Institute. Dr. Jigisha Shah Fellow, Bombay City Eye Institute INTRODUCTION: ARMD is a leading cause of central vision loss in patients older than 50 years of age. The majority of eyes suffer severe vision loss as a result of choroidal neovascularization, the only proven effective treatment for which is laser photocoagulation. The Macu...

through the formation of early products such as Schiff base and Amadori rearrangement products, to the formation of advanced glycation endproducts (AGEs). Ne-(Carboxymethyl)lysine (CML), a major structure in AGEs, is accumulated in several tissues of human and animal during aging and various disease states including age-related macular degeneration (AMD). Choroidal neovascularization leads the ...

Tumors provide an extremely abnormal microenvironment that stimulates neovascularization from surrounding vessels and causes altered gene expression within vascular cells. Up-regulation of vascular endothelial growth factor (VEGF) receptors has allowed selective destruction of tumor vessels by administration of a chimeric protein consisting of VEGF121 coupled to the toxin gelonin (VEGF/rGel). W...

OBJECTIVES To determine the role of extracellular proteinases in ischemia-induced retinal neovascularization in an animal model and to examine the effect of proteinase inhibitors on retinal neovascularization. METHODS Retinal neovascularization was induced in newborn mice exposed to 75% oxygen for 5 days, followed by room air. Retinal extracts underwent zymographic analysis to measure the act...