We sought to investigate the usefulness of the adeno-associated virus 2 (AAV)-based vectors to suppress the excess production of the human alpha-globin gene product towards developing a treatment modality for beta-thalassemia since accumulation of free alpha-globin reduces the lifespan of red blood cells in these patients. We constructed recombinant AAV virions containing the human alpha-globin...

Recombinant adeno-associated virus 2 (AAV) virions were constructed containing a gene for resistance to neomycin (neoR), under the control of either the herpesvirus thymidine kinase (TK) gene promoter (vTK-Neo), or the human parvovirus B19 p6 promoter (vB19-Neo), as well as those containing an upstream erythroid cell-specific enhancer (HS-2) from the locus control region of the human beta-globi...

â  lake urmia, the third hyper-saline lake in the world and because of its climatic, economic, social and ecological/environmental importance is a populated region in iran. recently, severe drought periods and low water levels are causing problems in this lake. therefore, it is urgent and desirable to evaluate urmia water level fluctuations in a scientific ways. urmia lake water level the same ...

background: urmia lake, the second largest hyper-saline lake of the world, has experienced lack of water and other environmental issues in recent years. now, there is a danger of the lake drying out, which will affect the region and its inhabitants. this study aimed to present a model which can relate the water level of the lake to effective factors. methods: parameters that influence water lev...

the zerebar lake is a shallow freshwater lake located in the northwestern iran. the lake is surrounded by three human activities: agriculture, tourism and dam. the present study aimed to investigate (1) which human activity has the greatest impact on eutrophication of the zerebar lake (2) if phytoplankton communities, as the indicator, are correlated with the human activities. water samples wer...