introduction: this study was aimed to asses the rate of recurrence after the first unprovoked seizure in children. methods and materials: in a prospective study, we recruited 145 children who presented with primary unprovoked seizure and were followed for at least 12 months after the first seizure. results: seventy five children (51.7%) experienced subsequent seizures. the cumulative risk of se...

Management of seizure activity in the neonatal foal presents a number of challenges. Control of neurological dysfunction and prevention of secondary physical injury is necessary in the first instance. Diagnosis of any underlying medical conditions must occur. Wide-ranging knowledge of the underlying cerebral pathology is essential when formulating a treatment plan. The relatively limited knowle...

Background: Seizures affect 1.5 - 1.3/1000 live births at term and are associated with worse neurodevelopmental outcomes. 80-90% of neonatal seizures subclinical. Amplitude integrated electroencephalography raw EEG video images (video aEEG/EEG) is an alternative for seizure assessment the bedside.

Neonatal seizures pose a high risk for adverse outcome in survived infants. While the prognostic value of amplitude-integrated electroencephalogram (aEEG) is well established in neonates with encephalopathy and asphyxia, neonatal seizure studies focusing on the direct correlation between early aEEG measurement and subsequent neurologic outcome are scarce. In this study, the prognostic value of ...

Neonatal seizures are amongst the most common neurologic conditions managed by a neonatal care service. Seizures can exacerbate existing brain injury, induce "de novo" injury, and are associated with neurodevelopmental disabilities in post-neonatal life. In this mini-review, we present evidence in support of the use of ganaxolone, a GABAA agonist neurosteroid, as a novel neonatal therapy. We di...

The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG. Fifty eight of 283 (4.5%) neonates in tertiary level neonatal intensive care had seizures. The mortality in the infants with neonatal seizures was 36.2%. In 31 su...