It remains unclear whether mild hypothermia affects energy metabolism in the brain tissue of newborns with hypoxic-ischaemic encephalopathy (HIE). The current study aimed to investigate the effect of mild hypothermia on energy metabolism in neonatal HIE and assess brain energy metabolism using position emission tomography/computed tomography (PET/CT) scanning. The mean standardised uptake value...

BACKGROUND Families must process complex information related to neonatal encephalopathy and therapeutic hypothermia. METHODS In this mixed methods study, semi-structured interviews were performed with parents whose infants were enrolled in an existing longitudinal cohort study of therapeutic hypothermia between 2011 and 2014. RESULTS Thematic saturation was achieved after 20 interviews. Par...

Abstract The aim of this paper is to explore the diagnosis known as Hypoxic Ischemic Encephalopathy (HIE) and an intervention called body cooling or therapeutic hypothermia. This literature review will relate clinical setting investigate implications for neonatal nurse practitioner (NNP). research define discuss incidence, etiology, pathophysiology, diagnosis, management, NNP. Discussion HIE wa...

OBJECTIVE Therapeutic hypothermia has become a standard neuroprotective treatment in term newborn infants following perinatal asphyxia. Active cooling with whole body surface or head cooling is complex, expensive and often associated with initial hypothermic overshoot. We speculated that passive cooling might suffice to induce and maintain hypothermia. METHODS We analysed 18 asphyxiated term ...

Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. Therefore, in this brief overview we discuss both the clinical evidence an...

Abstract Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of brain damage in newborns. Although therapeutic hypothermia has been shown to be neuroprotective against neonatal HIE clinical trials, its effect not satisfactory. Cell-based therapies have attracted much attention as novel treatments for HIE. Preclinical studies on variety human cell transplantation methods performed im...

BACKGROUND Neonatal hypothermia is associated with an increased mortality risk for 28 days. There are few community-based data on specific risk factors for neonatal hypothermia. Estimates of association between neonatal hypothermia in the community and risk factors are needed to guide the design of interventions to reduce exposure. METHODS A cohort of 23,240 babies in rural southern Nepal was...

Aims Hypoxic-ischemic injury (HI) to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term borns with hypoxic-ischemic encephalopathy, saving one in eight infants from developing severe neurological deficits. Therefore, additional treatments with clinically applicable drugs are indispensable. Furthermo...