OBJECTIVE To assess the effect of cesarean delivery on neonatal and maternal morbidity and mortality and their associated costs for two populations of women presenting with genital herpes lesions at delivery: those with and those without a history of genital herpes. DATA SOURCES MEDLINE (search for herpes simplex virus and neonatal, cesarean, and mortality) and recognized experts. DATA EXTR...

BACKGROUND Neonatal infection with herpes simplex virus (HSV) is not a nationally reportable disease; there have been few population-based measures of HSV-related infant mortality. We describe infant death rates due to neonatal HSV as compared with congenital syphilis (CS) and HIV, 2 reportable, perinatally transmitted diseases, in New York City from 1981 to 2013. METHODS We identified neonat...

introduction: herpes zoster infection (hzi) is a viral disease with painful skin rashes and blisters in a limited area on one side of the body, often in a strip. osteonecrosis with spontaneous exfoliation of teeth in association with hzi of the mandibular nerve is a rare phenomenon. in this report, such an unusual complication of hzi is presented.   case report: the clinical course of a 53-year...

This report provides an update on the surveillance conducted by the Australian Paediatric Surveillance Unit (APSU) during the period 1 January to 31 December 2012. The APSU, now in its 20th year of operation, continues to facilitate national active surveillance of uncommon communicable diseases of childhood. In 2012, the APSU conducted national surveillance for acute flaccid paralysis (AFP), co...

While antibody responses to neurovirulent pathogens are critical for clearance, the extent to which antibodies access the nervous system to ameliorate infection is poorly understood. In this study on herpes simplex virus 1 (HSV-1), we demonstrate that HSV-specific antibodies are present during HSV-1 latency in the nervous systems of both mice and humans. We show that antibody-secreting cells en...

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause prevalent, chronic infections that have serious outcomes in some individuals. Neonatal herpes may occur when the infant traverses the cervix during maternal genital herpes. Genital herpes is a major risk factor for human immunodeficiency virus type 1 transmission. Considerable efforts have been made to design and test vaccines for HSV, ...

We have developed and tested a method for printing protein microarrays on glass slides and using these microarrays in a comparative fluorescence assay to detect TORCH infections. We generated protein microarrays by printing antibodies to simultaneously determine infections of TORCH (toxoplasmosis-rubella-cytomegalovirus-herpes) by detecting antibodies against Toxoplasma gondii, rubella virus, c...

conclusion we suggest the standard cefazolin prophylaxis (after cord clamping) for elective cesarean section and cefazolin before incision for non elective cesarean section. therefore, administration of prophylactic cefazolin prior to incision will not increase the rate of neonatal sepsis. compared between these groups. results two groups were demographically identical. rate of iv line need (rr...