OBJECTIVE To determine the pattern of liver diseases diagnosed in children at Ga-Rankuwa Hospital Histopathology Laboratory. DESIGN A retrospective study. SETTING Ga-Rankuwa Histopathology Laboratory. SUBJECTS Seventy two patients who underwent a liver biopsy during the study period. METHODS Laboratory records were reviewed and all liver biopsies were extracted. All slides were reviewed...

Background: The spectrum of hepatobiliary disorders in children is different from those of adults and include a variety of acute and chronic disorders and these variations are attributable to different factors and they vary with geographical area.Therefore, there is need of such study to find out the spectrum of hepatobiliary diseases in different areas. Aim:To find out the existing pattern of ...

AIMS To investigate the distribution of alpha and pi class glutathione S-transferases (GST) in normal fetal, neonatal, and adult liver; and to examine changes in GST expression in neonatal liver disease. METHODS alpha and pi class GST were immunolocalised in sections of formalin fixed liver tissue obtained from human fetuses (n = 21), neonates (n = 8), young children (n = 9) and adults (n = 1...

Introduction: Early differentiation of biliary atresia from neonatal hepatitis is of utmost importance, since on time surgery of biliary atresia significantly improves the outcome. Hepatobiliary scintigraphy is an integral part of diagnosis work-up of these patients; however its specificity for diagnosis of biliary atresia is suboptimal. In this study we evaluated the value of ursodeoxycholic a...

Mowat, A. P., Psacharopoulos, H. D., and Williams, R. (1976). Archives of Disease in Childhood, 51, 763. Extrahepatic biliary atresia versus neonatal hepatitis: review of 137 prospectively investigated infants. In a prospective regional survey of neonatal hepatitis syndrome 32 infants had extrahepatic biliary atresia (EHBA) and 103 had hepatitis. No cause for the lesion was found in infants wit...

The objective of this study was to study etiologies and outcome of neonatal cholestasis in Thai infants. The medical records of infants aged less than 3 months with the diagnosis of neonatal cholestasis in Department of Pediatrics, Siriraj Hospital from 1993 to 2004 were retrospectively reviewed. The etiologies were diagnosed by history, physical examination, and proper investigations. There we...

Five out of 28 infants investigated in a regional survey of neonatal hepatitis were found to have genetically-determined deficiency of ai-antitrypsin (ZZ phenotype). The clinical course and pathological changes varied considerably. All five infants had an acute hepatitis-like illness, and although this subsided cirrhosis later developed in three cases. The remaining two infants had minimal abno...

In pediatric practice it was not infrequent to meet with a difficulty in etiological diagnosis for neonatal jaundice. For example, both neonatal hepatitis and atresia of the bile duct would present similar clinical and laboratory findings of "obstructive jaundice", and while an early surgical treatment is recommended for the cases with atresia of the bile duct, the therapy for those of neonatal...

Neonatal Lupus Erythematosus (NLE) is an uncommon condition manifesting with congenital complete heart block and occasionally other manifestations like hepatitis. Neonatal Lupus with severe cholestasis with positive anti SS-A/Ro and anti SS-B/La antinuclear antibodies in the mother and child is being reported.

An increasing number of infertile, hepatitis B virus-infected individuals have opted for assisted reproductive technology. However, the impact of the hepatitis B virus carrier serostatus on neonatal outcomes has not been evaluated. Data from 504 patients who delivered singletons were analyzed. In females, hepatitis B surface antigen, hepatitis B e antigen, and antibody to hepatitis core antigen...