We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient's disease course and elaborate upon mechanistic reasons for her improvement related to ustekinuma...

The Koebner phenomenon (KP) was first introduced by Heinrich Koebner in the 1870s to describe the appearance of psoriatic lesions following trauma in psoriasis patients. KP has since been defined in numerous diseases, including necrobiosis lipoidica diabeticorum (NLD). Since most Koebnerized dermatological lesions can localise to a site of previous trauma, Weiss et al. (Eur Acad Dermatol Venere...

5. Van Esso DL. Los padres frente a la vacunación. Vacunas. 2010;11:133--4. 6. Jiménez Gómez N, Ballester Martínez MA, Alcántara González J, Jaén Olasolo P. Koplik spots as a diagnostic clue in a case of measles. Med Clin (Barc). 2012;139:560. 7. Lefebvre N, Camuset G, Bui E, Christmann D, Hansmann Y. Koplik spots: a clinical sign with epidemiological implications for measles control. Dermatolo...

A 56-year-old Caucasian male with a history of uncontrolled diabetes mellitus and multiple other comorbidities was evaluated for slowly expanding plaques of his right lower leg, left forearm and left dorsal hand that had been present for the past six years. The patient denied any associated pruritus or pain. There was no history of previous trauma, immunosuppression, recent travel or prior trea...