BACKGROUND Studies suggest an effect of nebulized hypertonic saline solution on air-flow limitation in subjects with respiratory syncytial virus (RSV) bronchiolitis, but results are based on subjective scores of clinical severity and are not clear. In this observational study, we used a noninvasive computerized tool to quantify wheezing before and after nebulization with hypertonic saline in ch...

Objectives. Antimicrobial activities of non-thermal atmospheric plasma-treated liquids on various bacterial and fungal strains in their planktonic and biofilm forms have been widely reported. Since most of the plasmatreated liquids are water based, they might be washed off certain surfaces and they cannot be applied for the infections of respiratory tract. In the present study we have tested an...

We wished to study the effect of airways secretion on gas exchange. Peripheral airway secretion was simulated in 9 rabbits by the continuous inhalation of nebulized isotonic saline, at a droplet size of about 3 microns. Intrapulmonary deposition of saline in the peripheral airways (83% in airways smaller than 0.5 mm) did not alter total inspiratory resistance (mean 5.4 kPa.l-1.s), but led to a ...

Pulmonary coagulopathy is intrinsic to pulmonary injury including pneumonia. Anticoagulant strategies could benefit patients with pneumonia, but systemic administration of anticoagulant agents may lead to suboptimal local levels and may cause systemic hemorrhage. We hypothesized nebulization to provide a safer and more effective route for local administration of anticoagulants. Therefore, we ai...

BACKGROUND AND OBJECTIVES Continuous administration of aerosolized beta 2-agonists has been suggested as an effective treatment for severe reversible airways disease. To facilitate continuous therapy and avoid a feed system for small-volume nebulizers (SVNs), a large-volume medication nebulizer (Vortran HEART) was developed. The goal of this study was to determine actual drug delivery of the HE...

backgroundbronchiolitis is the commonest cause of lower respiratory tract infection in infant. respiratory syncytial virus is the commonest cause of bronchiolitis. this study aimed to assess the efficacy of nebulized 3% hypertonic saline and salbutamol in the treatment of acute bronchiolitis in comparison with nebulized 0.9% saline and salbutamol.materials and methodsa prospective case second m...

objective(s): abdominal adhesions are one of the most important problems, occurring after intra-abdominal surgery in more than 90% of cases. this condition is the leading cause of bowel obstruction, infertility, and abdominal/pelvic pain. gold nanoparticles (gnps) have been shown to be non-toxic and exhibit anti-inflammatory, anti-angiogenic and antioxidant activities. the purpose of this study...

Noninvasive ventilation (NIV) has become a standard of care for patients with exacerbation of COPD and cardiogenic pulmonary edema. Studies have also sought to determine the effectiveness of NIV in exacerbation of asthma. Studies have investigated radioaerosol particle distribution to help explain the effects of NIV in normals and in those with asthma. In addition, NIV has been combined with ne...

Surface acoustic waves (SAW) can be generated along the surface of a piezoelectric material and efficiently transferred into fluid deposited on the surface to induce its nebulization. Recently, we demonstrated that surface acoustic wave nebulization (SAWN) can produce ions that are readily detectable by mass spectrometry (MS). Here we present the detailed fabrication process of a SAWN chip and ...