نتایج جستجو برای: ncx3
تعداد نتایج: 85 فیلتر نتایج به سال:
We investigated the properties and interaction domains of SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a newly synthesized and selective Na /Ca exchange (NCX) inhibitor. SN-6 (0.3–30 M) inhibited preferentially intracellular Na -dependent Ca uptake (i.e., the reverse mode) compared with extracellular Na -dependent Ca efflux (i.e., the forward mode) in NCX1-tr...
Downstream regulatory element antagonist modulator (DREAM) is a Ca(2+)-binding protein that binds DNA and represses transcription in a Ca(2+)-dependent manner. Previous work has shown a role for DREAM in cerebellar function regulating the expression of the sodium/calcium exchanger 3 (NCX3) in cerebellar granular neurons to control Ca(2+) homeostasis and survival of these neurons. To achieve a g...
The cardiac sarcolemmal Na+/Ca2+exchanger plays a primary role in Ca2+ efflux and is important in regulating intracellular Ca2+ and beat-to-beat contractility. Of the three Na+/Ca2+exchanger genes cloned (NCX1, NCX2, and NCX3), only NCX1 is expressed in cardiac myocytes. NCX1 has alternative promoters for heart, kidney, and brain tissue-specific transcripts. Analysis of the cardiac NCX1 promote...
Alzheimer’s disease (AD) is a widespread neurodegenerative disorder, affecting large number of elderly individuals worldwide. Mitochondrial dysfunction, metabolic alterations, and oxidative stress are regarded as cooperating drivers the progression AD. In particular, impairment amplifies production reactive oxygen species (ROS), resulting in detrimental alterations to intracellular Ca2+ regulat...
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