Ataxia Telangiectasia (AT) cells exhibit suboptimal activation of radiation-induced cell cycle checkpoints despite having a wild type p53 genotype. Reducing or eliminating this delay could restore p53 function and reinstate normal cellular response to genotoxic stress. Here we show that the levels of Nuclephosmin (NPM), NPM phosphorylated at Serine 125, p53, p53 phosphorylated at Serine 15 and ...

This paper develops a delay-insensitive (DI) digital design paradigm that utilizes ternary logic as an alternative to dual-rail logic for encoding the DATA and NULL states. This new Delay-Insensitive Ternary Logic (DITL) paradigm is compared with other DI paradigms, such as Pre-Charge HalfBuffers (PCHB) and NULL Convention Logic (NCL), showing that DITL significantly outperforms PCHB and NCL in...

The paper is a respond to the recently growing quest for hybrid approaches trying to integrate various AI paradigms in order to overcome their limitations. It presents a network modeling environment, called Net-clause language (NCL). NCL ooers distributed computational environment using data-driven control and spreading activation. Though it falls basically in the symbolic paradigm, NCL exhibit...

A bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl was assembled from a long-chain single-stranded DNA synthesized by rolling-circle amplification (RCA). Multiple GC-pair sequences were integrated into the ...

Salt stress inhibits soybean growth and reduces gain yield. Genetic improvement of salt tolerance is essential for sustainable soybean production in saline areas. In this study, we isolated a gene (Ncl) that could synchronously regulate the transport and accumulation of Na(+), K(+), and Cl(-) from a Brazilian soybean cultivar FT-Abyara using map-based cloning strategy. Higher expression of the ...

Muscle specimens obtained at necropsy from four cases of neuronal ceroid-lipofuscinosis (NCL), three of the juvenile and one of the late infantile type, and a muscle biopsy from a fifth patient with the juvenile type of NCL, all showed curvilinear bodies typical of NCL within the muscle fibres. The pigments were autofluorescent. It appears that skeletal muscle is a reliable tissue source for th...

This paper describes two architectures for designing asynchronous NULL Convention Logic (NCL) Booth2 multipliers. The first is better suited for a non-pipelined implementation, while the second is best for a high throughput pipelined realization. The two architectures are compared in terms of area and speed, using a gate-level NCL VHDL library with gate delays generated from physical level simu...

Dopamine (DA) in mammalian associative structures, such as the prefrontal cortex (PFC), plays a prominent role in learning and memory processes, and its homeostasis differs from that of DA in the striatum, a sensorimotor region. The neostriatum caudolaterale (NCL) of birds resembles the mammalian PFC according to connectional, electrophysiological, and behavioral data. In the present study, DA ...

A self-timed ring using NULL convention logic (NCL) is presented. An analytical method to evaluate the speed of NCL rings has been developed. The analytical predictions are verified by a Synopsys simulation and excellent agreement between the theoretical predictions and simulation results is obtained. Some important principles for ring optimisation are obtained. The analysis leads to the speed ...