نتایج جستجو برای: natural allergen
تعداد نتایج: 493191 فیلتر نتایج به سال:
Premarket, genetically modified (GM) plants are assessed for potential risks of food allergy. The major risk would be transfer of a gene encoding an allergen or protein nearly identical to an allergen into a different food source, which can be assessed by specific serum testing. The potential that a newly expressed protein might become an allergen is evaluated based on resistance to digestion i...
The timothy grass pollen allergen Phl p 1 belongs to the group 1 of highly cross-reactive grass pollen allergens with a molecular mass of ∼25-30 kDa. Group 1 allergens are recognized by >95% of grass pollen allergic patients. We investigated the IgE recognition of Phl p 1 using allergen-specific IgE-derived single-chain variable Ab fragments (IgE-ScFvs) isolated from a combinatorial library con...
BACKGROUND Allergies to grass pollen are the number one cause of outdoor hay fever. The human immune system reacts with symptoms to allergen from pollen. OBJECTIVE We investigated the natural variability in release of the major group 5 allergen from grass pollen across Europe. METHODS Airborne pollen and allergens were simultaneously collected daily with a volumetric spore trap and a high-v...
The house dust mite is a major cause of respiratory allergy worldwide. The management of mite allergy is based on avoidance measures, drug treatment, and allergen immunotherapy, but only allergen immunotherapy is able to modify the natural history of the disease. Injectable subcutaneous immunotherapy was introduced a century ago, while sublingual immunotherapy was proposed in the 1980s and emer...
Early rise in exhaled nitric oxide and mast cell activation in repeated low-dose allergen challenge.
Repeated low-dose allergen inhalation challenge mimics natural allergen exposure, providing a model for early mechanisms in the triggering of asthma. The current authors performed a controlled study to evaluate the time course of changes in exhaled nitric oxide fraction (F(e,NO)) and urinary biomarkers of airway inflammation. Eight subjects with mild allergic asthma completed two 7-day repeated...
OBJECTIVE Using a model of natural allergen exposure, we examined the effect of regular treatment with salmeterol on allergen-induced changes in airway responsiveness and exhaled nitric oxide (ENO). DESIGN Double-blind, randomized, parallel-group study. SETTING Specialist allergy unit in a university hospital. PATIENTS Asthmatic patients sensitized to pollen allergens were randomly alloca...
BACKGROUND The effect of allergen exposure on airway responsiveness and exhaled nitric oxide (NO) has been well documented, but no information is available on allergen-induced changes in the response plateau to adenosine 5'-monophosphate (AMP) and in bronchial NO flux (J'aw(NO)) and alveolar NO (CA(NO)). OBJECTIVES To determine the effect of natural allergen exposure, a proinflammatory stimul...
Cladosporium herbarum is an important allergenic fungal species that has been reported to cause allergic diseases in nearly all climatic zones. 5-30% of the allergic population displays IgE antibodies against molds. Sensitization to Cladosporium has often been associated with severe asthma and less frequently with chronic urticaria and atopic eczema. However, no dominant major allergen of this ...
BACKGROUND Latex sensitisation is recognised as a health problem among health care workers (HCWs) using latex products. The aim of this study was to quantify specific latex allergens in latex devices used in South African academic dental schools. The current study also compared the total protein content and the levels of specific allergens in these products. METHODS Fourteen latex examination...
This article reviews the recent advances and current state of equipoise in the use of immunotherapy for IgE-mediated food allergy. It examines the various methods currently under evaluation for induction of desensitisation and tolerance in food allergy and encompasses permissive diets which allow for inclusion of extensively heated food allergens, specific oral tolerance induction (SOTI), the u...
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