BACKGROUND AND PURPOSE Intra-arterial recanalization therapy (IAT) is increasingly used for acute stroke. Despite high rates of recanalization, the outcome is variable. We attempted to identify predictors of outcome that will enable better patient selection for IAT. METHODS All patients who underwent IAT at the University of Texas Houston Stroke Center were reviewed. Poor outcome was defined ...

BACKGROUND AND PURPOSE The σ-1 receptor (Sig-1R) agonist cutamesine (SA4503) enhanced functional recovery after experimental stroke with a treatment initiation window of 48 hours and chronic treatment for 28 days. We conducted a phase 2 clinical trial exploring the safety, tolerability, dose range, and functional effects of cutamesine in patients with ischemic stroke. METHODS Subjects were ra...

BACKGROUND AND PURPOSE Thrombolysis for acute ischemic stroke in patients aged > 80 years is not approved in some countries due to limited trial data in the very elderly. We compared outcomes between thrombolysed and nonthrombolysed (control) patients from neuroprotection trials to assess any influence of age on response. Method-Among patients with ischemic stroke of known age, pretreatment sev...

BACKGROUND AND PURPOSE Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). METHODS Patients with proximal middle cerebral artery occlusions included in our prospective stroke registry were identified. Patients presenting with ...

BACKGROUND AND PURPOSE An accurate long-term outcome prediction may improve management of stroke patients. We investigated the ability of copeptin to predict 1-year outcome in stroke patients. METHODS In this preplanned post hoc analysis, the National Institutes of Health Stroke Scale score and copeptin levels were measured on admission in a cohort of patients with ischemic stroke. The primar...

HomeStrokeVol. 52, No. 1National Institutes of Health Stroke Scale as an Outcome Measure for Acute Trials Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBNational José-Miguel Yamal and James C. Grotta YamalJosé-Miguel Correspondence ...

BACKGROUND We sought to determine if the National Institutes of Health Stroke Scale (NIHSS) has a greater discriminative power than Glasgow coma scale (GCS) identify patients at risk poor early functional outcomes and large hematoma volumes. METHODS prospectively collected clinical assessments, imaging, outcome data in consecutive with intracerebral hemorrhage, determined ability GCS NIHSS pred...

BACKGROUND AND PURPOSE The efficacy of pharmacological thrombolysis using tissue plasminogen activator depends on the relative fibrin content of the thrombus. We investigated whether patients with stroke with a right-to-left shunt (RLS), whose embolic source was associated with fibrin-rich thrombus formed in the venous system, were more likely to improve dramatically after thrombolytic therapy ...