Cancer stem cells are regarded as the cause of tumour formation and recurrence in nasopharyngeal carcinoma (NPC). However, ideal surface markers for stem cells in NPC remain unidentified. In the present study, we investigated the expression of CD133, Nanog and Sox2 in the nasopharyngeal carcinoma cell line CNE2 and primarily cultured NPC cells using immunofluorescence or flow cytometry. A cell ...

The Chinese in California have an incidence of nasopharyngeal cancer roughly of the order of magnitude of the very high rate in Southeast Asia. Filipino migrants to Cal ifornia have a nasopharyngeal cancer risk intermediate to the high risk for Chinese and the low risk for Caucasians. A study of nasopharyngeal cancer mortality over the pe riod 1958 to 1972 shows a gradient of lower risk of the ...

Postradiation nasopharyngeal necrosis is an important late effect of radiotherapy that affects prognosis in patients with nasopharyngeal carcinoma. In the present study, we reviewed the clinical and imaging features of 67 patients with pathologically diagnosed postradiation nasopharyngeal necrosis who were treated at Sun Yat-sen University Cancer Center between June 2006 and January 2010. Their...

Let-7a is frequently downregulated in various types of human cancer including nasopharyngeal carcinoma. However, the underlying mechanism of let-7a action in nasopharyngeal carcinoma remains elusive. In this study, we show that the enhancer of zeste homolog 2 (EZH2) is a direct target of let-7a in human nasopharyngeal carcinoma cells. The inhibiti...

Drs. Ali and Al-Sarraf have prepared a comprehensive review of current data on the role of chemotherapy in the management of nasopharyngeal cancer, a tumor of epithelial origin with a distinctive geographic and ethnic distribution. Although this disease has traditionally been categorized as a head and neck neoplasm, its natural history and responsiveness to therapy differ considerably from thos...

Background: Presence of artifacts, caused by dental filling high-Z materials (DFM), on intensity-modulated radiation therapy (IMRT) treatment plan CT images may lead to uncertainty in head and neck calculated dose distributions. Hence, the purpose of this study was to investigate the effects of DFM on the IMRT calculated dose distribution and consequent radiobiological derived outcomes for naso...