Postherpetic neuralgia (PHN) is a common complication of herpes zoster, frequently unresponsive to most available treatment. The disease is especially difficult to manage in elderly people and has a great impact on the quality of life of patients. Narrow band ultraviolet B radiation may play a role in the prevention and treatment of PHN. Present paper describes a case of a 59 year-old female pa...

OBJECTIVE This study attempts to objectively measure physiological changes in transepidermal water loss (TEWL), an indicator of skin barrier function and laser Doppler perfusion index (LDPI) an indicator of skin vascularity, of psoriatic skin lesions following treatment to narrow-band ultraviolet B (UVB) phototherapy using the psoriasis severity (PS) score as a measurement of clinical photother...

Narrow-band UVB (NB-UVB) phototherapy is commonly used for treatment of psoriasis, though the mechanisms underlying its efficacy have not been completely elucidated. We used gene expression profiling to characterise gene expression in lesional epidermis from psoriasis patients in the middle and late stages of NB-UVB photo-therapy. Increased melanogenesis gene expression was the earliest respons...

BACKGROUND The Dead Sea basin, the lowest terrestrial point on earth, is recognized as a natural treatment center for patients with various cutaneous and rheumatic diseases. Psoriasis is the major skin disease treated at the Dead Sea with excellent improvement to complete clearance exceeding 85% after 4 weeks of treatment. These results were postulated to be associated with a unique spectrum of...