Lipid nanoparticles (LNPs) have attracted special interest during last few decades. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are two major types of Lipid-based nanoparticles. SLNs were developed to overcome the limitations of other colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles because they have advantages like good release profile ...

The present review compiles the applications of lipid nanoparticles mainly solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of pharmaceutical actives. The attempts to overcome the low solubility and bioavailability of some drugs by their incorporation into lipid nanocarriers have been summarized. A special focus of this review is on different routes of ad...

Abstract The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest significant entrants in development of drug delivery systems owing to their myriad advantages. NLCs second-generation SLNs having unstructured matrix, have high loading, provide long-term stability comparison other syst...

Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as biocompatible, non-toxic, safe nano-drug compared to polymeric or metallic nanoparticles. Due its safety, stability, high loading capacity other lipid-based nanocarriers, NLC gained ...

Nanostructured lipid carriers (NLCs), a lipid based colloidal carrier system, offer many advantages such as increase the solubility, improves the bioavailability and therapeutic efficacy. Incorporation of liquid lipid can improve the drug loading capacity in the NLCs. Valsartan is an antihypertensive drug with low oral bioavailability ranging from 10-35% because of poor solubility and extensive...

Nanostructured lipid carrier (NLC) is the blend of solid lipid, liquid lipid and suitable surfactant for the purpose of encapsulated poorly water soluble drugs. [6]-gingerol is the main bioactive compound in Zingiber officinale, widely known as ginger in Malaysia. Zingiber officinale extract has been discovered to have anti-oxidant, anti-inflammatory, and anti-microbial effects to human body. T...

The aim of this study is to prepare fluvastatin nanostructured lipid carriers (FLV-NLCs) in order to find an innovative way to alleviate FLV-associated disadvantages. The limitations include poor solubility and extensive first-pass metabolism, resulting in low (30%) bioavailability and short elimination half-life (1-3 hours). FLV-NLCs were prepared by hot emulsification-ultrasonication method. ...

Zerumbone, a natural dietary lipophilic compound with low water solubility (1.296 mg/L at 25°C) was used in this investigation. The zerumbone was loaded into nanostructured lipid carriers using a hot, high-pressure homogenization technique. The physicochemical properties of the zerumbone-loaded nanostructured lipid carriers (ZER-NLC) were determined. The ZER-NLC particles had an average size of...