5-fluoro-2’-deoxycytidine (FdCyd), a DNA methyltransferase inhibitor, has been shown to allow reexpression of tumor suppressor genes. However, in vivo, FdCyd experiences rapid metabolic conversion by cytidine deaminase (CD) to active cytotoxic metabolites 5-fluoro-2’-deoxyuridine (FdUrd), 5-fluorouracil (FU), and inactive 5-fluorouridine (FUrd). Preclinical studies coadministering FdCyd with a ...

Crystallization kinetics of Fe52Cr18Mo7B16C4Nb3 alloy was evaluated using X-ray diffraction, differential scanning calorimetric (DSC) tests and TEM observations in this research work. In effect, crystallization and growth mechanisms were investigated using DSC tests in four different heating rates (10, 20, 30, 40 K/min) and kinetic models (i.e. Kissinger- Starink, Ozawa, and Matusita methods). ...

Nanocrystals develop in amorphous alloys usually during annealing treatments with growth- or nucleation-controlled mechanisms. An alternative processing route is intense deformation and nanocrystals have been shown to develop in shear bands during the deformation process. Some controversy surrounded the idea of adiabatic heating in shear bands during their genesis, but specific experiments have...

PURPOSE This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for enhancing drug delivery properties. METHODS RIF NS was fabricated using the antisolvent precipitation technique. The impact of solvent type and flow rate, stabilizer type and concentration, and stirring time and apparatus together with the solvent-antisolvent volume ratio on its controlled nanocrys...