We explored the cytotoxic effects of nanobacteria (NB) and nanohydroxyapatites (nHAPs) against human choriocarcinoma cells (JAR) and the mechanisms of action underlying their cytotoxicity. JAR cells were co-cultured with NB and nHAPs for 48 h, and ultrastructural changes were more readily induced by NB than nHAPs. Autophagy in the plasma of JAR cells were observed in the NB group. The rate of a...

INTRODUCTION AND OBJECTIVES Calcifying nanoparticles, also known as "nanobacteria," are very small bacteria-like structures (0.1-0.5 μm) with the ability to facilitate the precipitation and growth of calcium phosphate in pathological conditions and have been associated with aortic valve calcification. The status of nanobacteria is controversial; some have proposed that they are a new class of l...

Microorganisms are one of the important factors for urinary calculi formation. While urease-positive bacteria and nanobacteria contribute to stone formation, Oxalobacter formigenes rods play a protective role against the development of urolithiasis. Proteus mirabilis alkaline environment of the urinary tract and cause crystallization mainly of struvite (magnesium ammonium phosphate). However, n...

Pathological calcification is becoming recognized as an important feature in the dynamics of a variety of diseases, such as renal stone, atherosclerosis, pulp stones, scleroderma and arthritis, etc. from which millions of human beings suffer in all ages. Nanobacterium sanguineum is the first calcium phosphate mineral containing nanoorganism isolated from human blood that causes pathological dis...

Publications Book. 2002;206A. Response We have proposed several potential explanations for the association between oral health and cardiovascular disease, and the activation or release of inflammatory mediators caused by bacteria is one.1–3 However, different measures of oral health, such as the number of remaining teeth, recent tooth loss, and periodontal disease that could reflect different p...