Nowadays, a real challenge in cancer therapy is to design drug delivery systems that can achieve high concentrations of drugs at the target site for improved therapeutic effect with reduced side effects. In this research, we designed and synthesized a homing peptide-(TNYLFSPNGPIA, TNYL) modified chitosan-g-stearate (CS) polymer micelle (named T-CS) for targeting delivery. The peptide displayed ...

This study was carried out to investigate an effective method for the co-delivery of Gemcitabine (GEM) and paclitaxel (PTX) into tumor cells. GEM and PTX were modified with functional (+)-a-tocopherol (VE) to obtain similar water solubility. Folic acid-poly(ethylene glycol)–(+)-a-tocopherol (FA–PEG–VE) was designed to co-encapsulate the modified GEM and PTX. Methoxy poly(ethylene glycol)–poly(l...

Age and diabetes related slow-healing or chronic wounds may result in morbidity mortality through persistent biofilms infections prolonged inflammatory phase. Nano-materials [metal/metal oxide NPs (39%), lipid vehicles (21%), polymer (19%), ceramic nanoparticles (NPs) (14%), carbon nanomaterials (NMs) (7%)] can be introduced as a possible next-generation therapy because of either their intrinsi...

Cytochrome P450s are heme-containing monooxygenases that require electron transfer proteins for their catalytic activities. They prefer hydrophobic compounds as substrates and it is, therefore, desirable to perform their reactions in non-aqueous media. Reversed micelles can stably encapsulate proteins in nano-scaled water pools in organic solvents. However, in the reversed micellar system, when...

We use a stochastic molecular dynamics simulation method to investigate the effect of optimal head group area in amphiphilic self-assembly. For a fixed tail geometry, we choose several sizes of the effective head group area and carry out a detailed study of how this affects the critical micelle concentration ~CMC!, the cluster distribution, and the shape of micelles for different concentrations...

Nano-sized polymeric amphiphilic micelle was prepared using the hydrophilic polysaccharide, oligo-chitosan, and hydrophobic side chains, ursolic acid which assists the skin penetration, because the amphiphilic polysaccharide nanoparticles have been widely investigated as the carriers for active agents such as small molecules, proteins, peptides, and nucleic acids due to many advantages in prote...

We present an in-silico-to-in-vitro approach to develop well-defined, self-assembled, rigid-cored polymeric (Polybee) nano-architecture for controlled delivery of a key component of bee venom, melittin. A competitive formulation with lipid-encapsulated (Lipobee) rigid cored micelle is also synthesized. In a series of sequential experiments, we show how nanoscale chemistry influences the deliver...

Interfacial properties rhamnolipids from an extract produced by a strain of Pseudomonas aeruginosa were analyzed in this study. The extract of rhamnolipid was characterized by surface tension in different conditions; interfacial tension with different hydrocarbons; critical micelle concentration under different pH and temperatures; particle size and emulsification capacity using laser light pro...

Preparing low energy liquid-repellant surfaces (superhydrophobic or superoleophobic) have attracted tremendous attention of late. In all these studies, the necessary liquid repellency is achieved by irreversible micro-nano texturing of the surfaces. Here we show for the first time that a glass surface, placed under water, can be made superoleophobic (with unprecedented contact angles close to 1...