To date there has not been any report on catan-ionic hybrid lipidic nano-carriers, let alone a report on applying them to deliver insoluble anti-tumor drugs. Catan-ionic hybrid lipidic nano-carriers containing curcumin (CUR-C-HLN) inherit the merits of catan-ionic systems, hybrid lipidic systems and nano-structured carriers (the second-generation substitute of solid lipidic nano-systems). Catan...

Objective: Diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance. Curcumin inhibits NF-κB signaling pathway. The aim of this study is evaluation of the effect of Nano-curcumin on HbA1C, fast blood glucose and lipid profile in diabetic patients. Materials and Methods:...

The Effect of Aerobic Exercise Training and Consumption Curcumin Nano Micelles on the Expression Level CASP3, CASP9, Bax BCL2 Genes Cardiac Tissues Balb/C Mice with Induced Breast Cancer Treated Doxorubicin

objective: in order to improve the water solubility and bioavailability of curcumin in cancer therapy, we prepared and tested a novel waterborne cationic polyurethane (pu) as a nano-carrier for curcumin loading (cu-pu). we studied the effect of this prepared nano-drug on melanoma (f10b16) and fibroblasts cells (l929). methods: morphology, size and cell internalization ability of the prepared n...

In this work, we investigate the loading and conjugation of Curcumin on oleic acid (OA) and citric acid (CA) functionalized iron oxide nanoparticles and its applications in improving contrast in MRI. Magnetic iron oxide nanoparticles (Fe3O4, MNPs) synthesized using the co-precipitation method and characterized by XRD, DLS, FT-IR, VSM and SEM. FT-IR results confirmed functionalization with oleic...

Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exert immunomodulatory effects via macrophages. However, most studies focus on the low bioavailability issue of curcumin by nano and microparticles, and thus the role of macrophages in the anticancer mechanism of curcumin has received little attention so far. We have previously shown the potential bioco...

Cancer is a multifactorial disease that requires treatments able to target multiple intracellular components and signaling pathways. The natural compound, curcumin, was already described as a promising anticancer agent due to its multipotent properties and huge amount of molecular targets in vitro. Its translation to the clinic is, however, limited by its reduced solubility and bioavailability ...

Curcumin is a polyphenolic compound derived from Curcuma domestica (Zingiberaceae) that possesses diverse pharmacological effects including anti-inflammatory, antioxidant, antimicrobial, and anticarcinogenic activities. Although phase I clinical trials have shown curcumin as a safe drug even at high doses (12 g/day) in humans, poor bioavaibility largely limits its pharmacological activity. Nano...

Nano fibrous membranes core-shell of poly(lactic acid) (PLA) and poly(?-caprolactone) (PCL), encapsulating 1 wt% curcumin, are fabricated by coaxial electrospinning technique. Morphology physical properties, as well the release studied compared with neat PLA PCL individually spinned. Morphological analysis shows for all samples obtainment fiber oriented in random way, without defect a narrow di...