AIM To investigate the role of 18F-NaF PET/CT and compare it with 99m Tc-MDP whole body bone scintigraphy and 18F-FDG PET/CT in detecting the extent of metastatic bone disease and to present our first experience with 18F-NaF PET/CT in our country. MATERIALS AND METHODS A total of 37 histopathologically proven cancer patients (22 male, 15 female) with bone metastasis detected on Tc-99m MDP who...

The bumetanide-sensitive component of pHi recovery from an NH4Cl-induced acute alkaline load was used as a measure of Na(+)-K(+)-2Cl- cotransport activity in rat parotid acini. Acinar treatment with NaF/AlCl3 (15 mM NaF plus 10 microM AlCl3) induced a 5-fold stimulation in the initial rate of bumetanide-sensitive pHi recovery. This effect was dependent on NaF concentration (K1/2 approximately 7...

We determined the centroid moment tensor (CMT) solutions of earthquakes that occurred along the North Anatolian fault (NAF) beneath the Sea of Marmara and the Aegean Sea, using data obtained from Turkey’s broadband seismograph network. The CMT solution of the 2014 Aegean Sea earthquake (Mw 6.9) represents a strike-slip fault, consistent with the geometry of the NAF, and the source-time function...

F-18 NaF PET/CT has been shown to have higher sensitivity than planar 99m-Tc MDP bone scanning in several studies. The concomitant acquisition of anatomic images permits immediate correlation of any abnormal findings. Additionally, F-18 NaF PET/CT bone imaging can be quantitated, allowing bone disease to be 'measureable', increasing its utility therapy monitoring. When a consistent F-18 NaF upt...

Polymorphonuclear leukocytes (PMNs) have increased oxidative metabolism during phagocytosis and emit light (chemiluminescence, CL) as a result of metabolic activation. The present study examined PMN CL in the absence of phagocytosis using sodium fluoride (NaF), a nonparticulate agent and known stimulator of cellular oxidative metabolism. Normal human and canine PMNs were assayed in a CL spectro...

To the Editor: Increased plasma homocysteine is regarded as a risk factor for arterial and venous occlusive disease. Sample collection ideally requires use of cooled EDTA containers and immediate centrifugation of the blood (1). These conditions may be hard to maintain in a clinic and are not possible in the many medical practices that lack a centrifuge. We tested whether analyzing uncentrifuge...

Rapid atrial pacing causes electrical remodeling that leads to atrial fibrillation (AF). AF can further remodel atrial electrophysiology to maintain AF. Our previous studies showed that there was a marked difference in the duration of AF in dogs that have been atrial paced at 400 beats/min for 6 wk. We hypothesized that this difference is based on the changes in the degree of electrical remodel...

The NEET proteins mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1) are required for cancer cell proliferation and resistance to oxidative stress. NAF-1 and mNT are also implicated in a number of other human pathologies including diabetes, neurodegeneration and cardiovascular disease, as well as in development, differentiation and aging. Previous studies suggested that mNT and ...

PURPOSE Nipple aspirate fluid (NAF) is considered a potential source for discovering breast cancer biomarkers. However, the success rate of obtaining NAF was reported to vary from 48% to 77%, and mechanisms for its secretion are not fully understood. The purpose of this study was to investigate dietary, demographic, reproductive, hormonal, and anthropometric factors that are associated with the...

BACKGROUND Detection of cytologic atypia in nipple aspirate fluid (NAF) has been shown to be a predictor of risk for development of breast carcinoma. Manual collection of NAF for cytologic evaluation varies widely in terms of efficacy, ease of use, and patient acceptance. We investigated a new automated device for the non-invasive collection of NAF in the office setting. METHODS A multi-cente...