BACKGROUND The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during development and tissue homoeostasis. However, Wnt5a signaling in breast cancer progression remains poorly defined. METHODOLOGY/PRINCIPAL FINDINGS We showed here that Wnt5a activated Dvl2, Daam1 and RhoA, and promoted migration of breast...

The performances of three recently published leaf sequencing algorithms for step-and-shoot intensity-modulated radiation therapy delivery that eliminates tongue-and-groove underdosage are evaluated. Proofs are given to show that the algorithm of Que et al (2004 Phys. Med. Biol. 49 399-405) generates leaf sequences free of tongue-and-groove underdosage and interdigitation. However, the total bea...

There is controversy over how hormonal conditions influence cerebral physiology. We studied pattern-shift visual evoked potentials (PS-VEP), brain stem auditory evoked potentials (BAEP) and short-latency somatosensory evoked potentials (SSEV) in 20 female volunteers at different phases of the menstrual cycle (estrogen phase, ovulatory day and progesterone phase). Statistical analysis showed dec...

Studi distribusi foraminifera untuk menentukan pola perubahan iklimpurba pada umur Pliosen dilakukan Formasi Sentolo. Daerah survei terletak di sebelah barat kota Yogyakarta. Secara regional daerah ini merupakan bagian dari Pegunungan Kulon Progo. Pengukuran stratigrafi dengan metode Tongkat Jacob total ketebalan lapisan 38,9 meter. Bagian bawah tersusun oleh perlapisan batupasir karbonatan-nap...

Abstract Background There is an increasing number of paediatric and adolescent patients being diagnosed with Inflammatory Bowel Disease (IBD) 1. Being at early age can have a detrimental effect on child’s development, so the need for support vital. Adult experiences living IBD are known 2 , but very little about experiences. This literature review aimed to identify explore how impacts their lif...

In a field experiment under rainfed conditions, reductions in cane yield over three crops due to infection by ratoon stunting disease (RSD) ranged from 41% to 19 % respectively in varieties N17, N14, N21, NCo376 and N19. Losses in Nl2 were 10%, and in N23 and N22 were 7% and 1%. In a similar trial conducted under irrigation, the greatest reductions in cane yield over two crops were 32% in varie...

Objective: A systematic review was carried out to determine the evidence for teaching pursed lips breathing (PLB) to patients with stable COPD. Exertional dyspnoea is the single most important factor limiting function for people with COPD and PLB is commonly advocated for its management. Method: A literature search of Medline, PEDro and CINAHL Plus was conducted. Articles were included if they ...

Highways frequently run through the flow and accumulation areas of debris gullies thus are susceptible to hazards. Assessing flows along highways can provide references for highway planners control, emergency management. However, existing assessment methods mostly neglect essential information paths spreading at regional scale. Taking Gaizi Village-Bulunkou Township Section (hereinafter referre...