PURPOSE Mutations in the ras genes often occur during tumorigenesis. In malignant melanoma, the most common ras alterations are N-ras codon 61 mutations. This study was aimed to measure the frequency of such mutations in a large series of paired primary and metastatic melanomas to determine their role in melanoma initiation and progression. EXPERIMENTAL DESIGN Seventy-four primary melanomas a...

BACKGROUND Mutations in codons 12, 13, and 61 of the N-ras gene are common alterations in cutaneous malignant melanoma. We evaluated pyrosequencing, a simple and rapid method used mainly for single-nucleotide polymorphism analysis, as a possible alternative to single-strand conformation polymorphism (SSCP) analysis and sequencing of N-ras. METHODS We evaluated the sensitivity and accuracy of ...

METHODSdRandomized, double-blind, 12-week study of 361 patients not on glucose-lowering therapy (HbA1c 7–10%) allocated to one of four once-daily subcutaneous dose increase regimens: lixisenatide 2-step (10mg for 1week, 15mg for 1week, and then 20mg; n = 120), lixisenatide 1-step (10 mg for 2 weeks and then 20 mg; n = 119), placebo 2-step (n = 61), or placebo 1-step (n = 61) (placebo groupswere...

Objective: To investigate the clinical effectiveness of minimally invasive subcutaneous pedicle screw and rod system in treatment of anterior pelvic ring injury. Methods: Altogether, 28 patients (17 men, 11 women; average age 39.8 years, range 19-68 years) with pelvic ring fractures were treated using a subcutaneous internal anterior fixation device composed of supra-acetabular spinal pedicle s...

BACKGROUND Thalamic hemorrhage (TH) is a neurological insult with a high rate of morbidity and mortality. Moderate TH (10-30 ml) accounts for more than half of all TH. Treatment remains controversial. The role of acupuncture in patients with moderate TH is not clear. METHODS We will conduct a single-center, randomized, parallel group, and assessor-blinded clinical trial. A total of 488 patien...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA KHANJARI G, RAHIMI M, KALANTARI N, et al. Study of exclusive breastfeeding behaviour based on the theory planned in pregnant women Isfahan 2021. Family Medicine & Primary Care Review. 2023;25(1):55-61. doi:10.5114/fmpcr.2023.125493. APA KHANJARI, G., RAHIMI, M., KALANTARI, N., AFSHAR, S., CHAHARLANG, A., DEHGHANI,...

To assess whether RAS oncogenes may affect the expression of cytokines in tumor cells, the presence of interleukins (IL) 1 alpha, 1 beta, 4, 6, 7, and 8, tumor necrosis factor (TNF) alpha and interferon gamma mRNA has been analyzed by reverse transcriptase-polymerase chain reaction in 19 melanoma clones derived from the metastatic cell line 665/2 and previously characterized for RAS mutation an...

The sacroiliac joint (SIJ) was considered the primary source of low back pain in the early 20th century (1). It became overshadowed by the herniated nucleus pulposus after the hallmark 1934 article by Mixter and Barr (2). Mounting evidence on computed tomography (CT), magnetic resonance imaging (MRI), and scintography demonstrating destructive, inflammatory, and degenerative pathology (3-9) sug...