We have performed a genome-wide analysis of common genetic variation controlling differential expression of transcript isoforms in the CEU HapMap population using a comprehensive exon tiling microarray covering 17,897 genes. We detected 324 genes with significant associations between flanking SNPs and transcript levels. Of these, 39% reflected changes in whole gene expression and 55% reflected ...

Many clinical and epidemiological studies have shown that the polyunsaturated n-3 fatty acids EPA and DHA from fish and fish oils, provide cardiovascular protection, particularly in the setting of secondary prevention. n-3 Fatty acids beneficially influence a number of cardiometabolic risk factors including blood pressure, cardiac function, vascular reactivity and lipids, as well as having anti...

Address correspondence to: Myriam Allende-Vigo, MD, FACP, FACE. University of Puerto Rico Medical Sciences Campus, School of Medicine, Internal Medicine Department, Endocrinology Division, PO Box 365067, San Juan, PR 00936-5067. Email: [email protected] Objective: This study aimed to establish a profile of the ultrasound-guided thyroid fine-needle aspiration biopsies (FNABs) performed at...

Introduction1 Taxation measures aiding the donation of gifts or bequests to the arts are applied on a major scale in the United States. Some of these measures have formed the cornerstone of government policy towards the arts in the United States since the beginning of the twentieth century and they are defended vehemently to this day. In contrast, while such measures exist in some countries in ...

TISTESüflOi'i ST^.TEMEITT^A Ä„„,..r~~~A -f.-i-r rjuWc release; Distribution Unlimited Two years ago, researchers at Sandia National Laboratories showed that a massively parallel computer with 1024 processors could solve scientific problems more than 1000 times faster than a single processor. Since then, interest in massively parallel processing has increased dramatically. This review paper disc...

Body fat distribution plays an important role in determining metabolic health. Whereas central obesity is closely associated with the development of CVD and type 2 diabetes, lower body fat appears to be protective and is paradoxically associated with improved metabolic and cardiovascular profiles. Physiological studies have demonstrated that fatty acid handling differs between white adipose tis...

Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. Although much is known about its interactions with microtubules, microtubule-binding proteins such as CLIP-170, and with the dynein motor complex, the response of Lis1 to neuronal motility signals has not been elucidated. Lis1 deficiency is associated with deregulation of the Rho-family GTPas...