We study the Crank–Nicolson scheme for stochastic differential equations (SDEs) driven by a multidimensional fractional Brownian motion with Hurst parameter H>1/2. It is well known that ordinary proper conditions on regularity of coefficients, achieves convergence rate n−2, regardless dimension. In this paper we show that, due to interactions between driving processes, corresponding m-dimension...

Dithiocarbamates (DTCs) are chemicals featuring a great chelating capacity. The toxicological study of DTCs is very important in view of their relatively simple synthesis and wide array of sanitary and industrial applications. In this study, the toxicity of some of the more recently synthesized DTCs is determined using an extremely simple bioassay, described in previous studies, based on the in...

Starting with tetrahydro-2H-thiopyran-4-carboxylic acid and methyl prolinate, the novel 2Hazirin-3-amine (S)-N-(1-aza-6-thiaspiro[2.5]oct-1-en-2-yl)proline methyl ester was synthesized. In reactions with benzoic acid, thiobenzoic acid and Boc-valine, respectively, its usefulness as a synthon for the dipeptide (S)-N-[(4-aminotetrahydro-2H-thiopyran-4-yl)carbonyl]proline in peptide synthesis was ...

A series of phthalimide derivatives planned as drugs candidates to treat the symptoms of sickle cell anemia were evaluated in a mutagenicity test using strains of Salmonella typhimurium TA100 and TA102, without and with addition of S9 mixture, with the aim to identify the best structural requirements for a drug candidate without genotoxic activity. The compounds (1,3-dioxo-1,3-dihydro-2H-isoind...

Based upon comprehensive theoretical investigations and known experimental observations, we predict the existence of the double-chain planar D(2h) B(4)H(2)(1), C(2h) B(8)H(2)(3), and C(2h) B(12)H(2)(5) which appear to be the lowest-lying isomers of the systems at the density functional theory level. These conjugated aromatic borenes turn out to be the boron hydride analogues of the conjugated e...

The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2- phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthes...

The title compound, {[Zn(C(14)H(16)N(5)O(3))(2)]·2H(2)O}(n) or [Zn(ppa)(2)]·2H(2)O}(n), where ppa = 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazin-yl)-pyrido(2,3-d)-pyrimidine-6-carboxyl-ate, was synthesized under hydro-thermal conditions. The Zn(II) atom (site symmetry ) exhibits a distorted trans-ZnN(2)O(4) octa-hedral geometry defined by two monodentate N-bonded and two bidentate O,O-bonded ppa mo...

In addition to its well-known roles as an electrophile and general acid, the side chain of histidine often serves as a hydrogen bond (H-bond) acceptor. These H-bonds provide a convenient pH-dependent switch for local structure and functional motifs. In hundreds of instances, a histidine caps the N-terminus of α- and 310-helices by forming a backbone NH···Nδ1 H-bond. To characterize the resilien...