نتایج جستجو برای: nω hydroxy nor l arginine
تعداد نتایج: 764458 فیلتر نتایج به سال:
Background—Endothelial dysfunction plays an important role in the early development of atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased expression and activity of arginase, metabolizing the nitric oxide substrate L-arginine, may result in reduced production of nitric oxide and thereby endothelial dysfunction. We hypothesized that inhibition of arginase activity ...
Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is critical for the development of ischemia-reperfusion injury. The aim of the study was to determine myocardial arginase expression and activity in ischemic-reperfusion myocardium and whether local inhibition of arginase within the ischemic myocardium results in increased NO production and protection aga...
هدف از انجام این تحقیق بررسی نقش احتمالی داروهای نیتریک ارژیک در اثرات پاداشی نیکوتین در موش بزرگ آزمایشگاهی نر بود. از یک روش ترجیح مکان شرطی شده یا cpp (conditioned place preference) برای اندازه گیری اثرات پاداشی نیکوتین استفاده شد و در روز تست علاوه بر نمره شرطی شدن تعداد رفتارهای وابسته به دوپامین نیز شمارش شد. نتایج نشان داد که تجویز داخل صفاقی نیکوتین باعث القای cpp معنی دار شد در حالی که...
background: the assessment of altered nitric oxide (no) availability is of potentially important diagnostic and prognostic significance. the present study is aimed to investigate the effect of l-arginine (as a natural no donor) supplementation on no metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial no production. methods: white male rabbits (n = 30) ...
Pulmonary hypertension (PH) is a heterogeneous disorder associated with a poor prognosis. Thus, the development of novel treatment strategies is of great interest. The enzyme arginase (Arg) is emerging as important player in PH development. The aim of the current study was to determine the expression of ArgI and ArgII as well as the effects of Arg inhibition in a rat model of PH. PH was induced...
Hypertension is a chronic disease affecting the whole world due to its clinical effects and complications. The reduction in release effect of NO one mechanisms hypertension formation. disrupts balance between oxidant antioxidant mechanisms. In this study, we aimed observe biochemical changes blood by treatment propolis, caffeic acid phenethyl ester (CAPE) pollen hypertensive rats via Nω-Nitro-L...
PURPOSE To investigate how neuronal nitric oxide synthase (nNOS) contributes to regulation of the retinal circulation during rest and flicker stimulation in cats. METHODS Using laser Doppler velocimetry, we measured the vessel diameter and blood velocity simultaneously and calculated the retinal blood flow (RBF) in feline first-order retinal arterioles. After intravitreal injections of Nω-Nit...
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