نتایج جستجو برای: myometrium

تعداد نتایج: 2097  

Journal: :Cellular & molecular biology letters 2003
Beata Modzelewska Tomasz Kleszczewski Anna Kostrzewska

The aim of this study was to investigate whether apamin-sensitive K(+)channels play a role in the NO induced relaxation of the human pregnant myometrium. Concentration-response curves for sodium nitroprusside (SNP) (10(-9)-10(-4)M) were constructed in the absence and presence of 10(-8)M apamin and 10(-7)M charybdotoxin (CTX). Preincubation with apamin resulted in a significant attenuation of th...

Journal: :Molecular human reproduction 2014
Ping Hou Lu Zhao Ye Li Fucheng Luo Shengdong Wang Junying Song Jie Bai

Uterine leiomyomas are benign tumors that develop from smooth muscle cells (SMCs). The reactive oxygen species (ROS) have been shown to be involved in the signaling pathways that stimulate proliferation of a variety of cell types. Thioredoxin-1 (TRX-1) is a redox-regulating protein, which is overexpressed in various tumors. In the present study, we investigated the expressions of TRX-1 and its ...

Journal: :American journal of physiology. Cell physiology 2000
W X Wu Q Zhang N Unno J B Derks P W Nathanielsz

In this study, we characterized the changes in the extracellular matrix proteoglycan decorin in pregnant intrauterine tissues in late gestation and in association with labor and delivery in sheep. In addition, we examined the effects of estradiol and progesterone on regulation of decorin mRNA expression in myometrium from the nonpregnant ovariectomized sheep. Using suppression subtractive hybri...

Journal: :The Journal of clinical endocrinology and metabolism 2001
D Cermik M Karaca H S Taylor

HOX genes are essential regulators of development in all multicellular organisms, including humans. We have previously shown that HOXA10 is expressed in the developing uterus and later in the adult human endometrium. HOX genes regulate endometrial development in response to sex steroids. Here, we demonstrate that HOXA10 is expressed in the myometrium as well. In situ hybridization reveals abund...

Journal: :The Journal of clinical endocrinology and metabolism 2004
Neil R Chapman G Nicholas Europe-Finner Stephen C Robson

In humans, the factors that govern the switch from myometrial quiescence to coordinated contractions at the initiation of labor are not well defined. The onset of parturition is itself associated with increases in a number of proinflammatory factors, many of which are regulated by the nuclear factor kappaB (NF-kappaB) family of transcription factors. The expression and DNA-binding activity of N...

Journal: :Molecular human reproduction 2002
A Z Xiao Y G Zhao E K Duan

Fatty acid amide hydrolase (FAAH) is involved in embryo development and implantation. Sex hormones down-modulate FAAH activity in the mouse uterus. However, the regulation of the FAAH gene in the uterus is unknown. Our results showed that FAAH mRNA is localized to uterine epithelial cells and circular myometrium during the estrous cycle. In ovariectomized rats, estradiol (E2) plus progesterone ...

Journal: :Journal of clinical pathology 2005
J M Beuker J J H M Erwich T Y Khong

AIMS To determine the frequency with which myometrium is removed during vacuum terminations of pregnancy or dilatation and curettage after miscarriage, and to relate these findings to subsequent placenta accreta or its proxies. METHODS Archival tissues from vacuum termination of pregnancy or dilatation and blunt curettage after miscarriage were examined for the presence of myometrium. The sub...

Journal: :Cancer research 2006
Nicole S Spoelstra Nicole G Manning Yujiro Higashi Douglas Darling Meenakshi Singh Kenneth R Shroyer Russell R Broaddus Kathryn B Horwitz Jennifer K Richer

The transcription factor ZEB1 (deltaEF1 in mice) has been implicated in cellular processes during development and tumor progression including epithelial to mesenchymal transition. deltaEF1 null mice die at birth, but heterozygotes expressing a LacZ reporter inserted into the deltaEF1 gene live and reproduce. Using these mice, we observed ZEB1 promoter activity in the virgin myometrium, and stro...

Journal: :The Yale Journal of Biology and Medicine 1986
G. Yarrington K. Fontwit J. P. Figueroa A. Massmann P. W. Nathanielsz

Cervical and uterine electromyograms (EMG) have been recorded from ovariectomized non-pregnant ewes. When the animals were infused with saline, the frequency of EMG events lasting less than 180 seconds was not different from those lasting more than 180 seconds. During infusion of estradiol at 100 micrograms X 24 hours-1 into the maternal jugular, the frequency of events less than 180 seconds in...

Journal: :International journal of clinical and experimental pathology 2015
Yao Tang Hongjing Ji Haiyan Liu Weirong Gu Xiaotian Li Ting Peng

Spontaneous preterm labor is an important complication in perinatology characterized by early onset myometrium contractions leading to labor at preterm. However, the exact mechanism that maintain uterine quiescence and promote increased uterine contractility during labor were incompletely defined. MicroRNAs is a class of short non-coding RNAs that regulate gene expression at the post-transcript...

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