In order to evaluate the relationship between regional myocardial perfusion and segmental dyskinesis, 22 open chest dogs were studied using ultrasound to register cardiac wall motion and radioactive labeled microspheres to determine myocardial perfusion. In six dogs, motion and perfusion were correlated at two levels of partial circumflex coronary artery occlusion followed by complete occlusion...

Automatic myocardial wall motion tracking in ultrasound images is an important step in analysis of the heart function. Existing methods for Myocardial Wall Tracking are not robust to artifacts induced by signal dropout, significant appearance or gain control changes. We present a unified framework for tracking the myocardium wall motion in real time with uncertainty handling and robust informat...

BACKGROUND Dysfunction after thrombolytic therapy of acute myocardial infarction (MI) may be reversible. Early after myocardial infarction, both reversible and irreversible injury may be manifested by regional wall motion abnormalities. Improved wall thickening during dobutamine infusion (dobutamine-responsive wall motion) may accurately identify reversibly injured segments. METHODS AND RESUL...

MRI provides a valuable tool for noninvasive evaluation of myocardial wall motion. Recently, multi-phase 2D DENSE MRI was developed to quantify cardiac strain in mice at high spatial and temporal resolution [1, 2]. DENSE methods for 3D displacement encoding have also been investigated [3]. Typically, these methods entail multiple acquisitions that are time consuming. In this project, we aimed t...

Background Patients with ischemic cardiomyopathy (CMP) often develop regional wall motion abnormalities (WMA) due to myocardial scarring, stunning or hibernation. Abnormal functioning myocardial segments without evidence of fibrosis on late gadolinium-enhancement cardiac magnetic resonance (LGE-CMR) are felt to represent stunned or hibernating myocardium, presumably with significant coronary ar...

Regional left ventricular wall motion was evaluated by two-dimensional echocardiographic techniques with fixedand floating-axis analytical algorithms in three groups of subjects: normal subjects (n = 15), patients undergoing uncomplicated coronary artery bypass graft surgery (CABG) (n = 10), and patients suffering perioperative myocardial infarction (n 27). In patients undergoing uncomplicated ...

Right ventricular apical pacing (RVAP) with a left bundle branch block on the electrocardiogram may result in regional wall motion abnormalities and decreased left ventricular function (LVF). Furthermore, perfusion defects in dipyridamole technetium-99m-methoxisobutylisonitrile ((99m)Tc-MIBI) myocardial perfusion imaging may occur despite a normal coronary angiogram. In a 68 years old patient, ...

OBJECTIVE To assess the prognostic value of wall motion abnormalities during the recovery phase of dobutamine stress echocardiography in addition to wall motion abnormalities at peak stress. METHODS Wall motion abnormalities were assessed at peak and during recovery phase of dobutamine stress echocardiography in 187 consecutive patients, who were followed for occurrence of cardiac events. R...

Current techniques for diagnosing perioperative myocardial infarction were studied in 58 patients who underwent coronary bypass surgery. All patients had preoperative and postoperative ECGs and technetium-99m stannous pyrophosphate myocardial scintigrams; serum CK-MB was measured immediately after surgery and daily for 3 days. Postoperative bypass graft visualization and left ventriculography w...

BACKGROUND Intramyocardial injection of vascular endothelial growth factor (VEGF) plasmid DNA was studied to demonstrate improvement of regional myocardial function. METHODS Twenty-one pigs that had undergone ligation of the left anterior descending coronary artery were randomly allocated to one of two treatments: intramyocardial injection of pCK-VEGF165 (VEGF group) or pCK-Null (control grou...