doxorubicin (dox) is an anthracycline antibiotic with broad spectrum anti-tumour activity. its effectiveness has been limited by the occurrence of dose-related myocardial and bone marrow toxicity. as oxidative stress is the main factor in dox-induced cardiotoxicity, we presumed that agents which enhance endogenous antioxidants can prevent dox induced cardiotoxicity. animals received either dox ...

The normal expression of myocardial mitochondrial enzymes is essential to maintain the cardiac energy reserve and facilitate responses to stress, but the molecular mechanisms to maintain myocardial mitochondrial enzyme expression have been elusive. Here we report that congestive heart failure is associated with a significant decrease of myocardial estrogen-related receptor-α (ERRα), but not per...

Baicalein, a flavonoid purified from the root of Scutellaria baicalensis Georgi, is well known for its anti-inflammatory and anti-oxidative properties. The present study aimed to evaluate the cardioprotective effect of baicalein in a rat model of acute myocardial infarction and investigate the potential molecular mechanisms of this effect. The acute myocardial infarction model was prepared by p...

The normal expression of myocardial mitochondrial enzymes is essential to maintain the cardiac energy reserve and facilitate responses to stress, but the molecular mechanisms to maintain myocardial mitochondrial enzyme expression have been elusive. Here we report that congestive heart failure is associated with a significant decrease of myocardial estrogen-related receptor(ERR ), but not peroxi...

Bee stings are commonly encountered worldwide. Various manifestations after bee sting have been described 1 . Local reactions are common. Unusually, manifestations like vomiting, diarrhoea, dyspnoea, generalised oedema, acute renal failure, hypotension and collapse may occur. Rarely vasculitis, serum sickness, neuritis and encephalitis have been described which generally develop days to weeks a...

OBJECTIVE To investigate the difference between myocardial injuries caused by nonaneurysmal subarachnoid hemorrhage (SAH) or aneurysmal SAH. PATIENTS AND METHODS A total of 92 inpatients with SAH at early stage (within 48h), who were treated in our hospital from 2008 to 2014 were enrolled in this study. Differences in cerebral-cardiac syndrome seen in perimesencephalic subarachnoid hemorrhage...

Serial measurements of the MB isoenzyme of creatine kinase, total creatine kinase, aspartate mainotransferase, and urea stable lactate dehydrogenase have been made in the serum of a series of 139 patients admitted with a diagnosis of suspected myocardial infarction. Serum MB isoenzyme measurements have also been made on postoperative surgical patients and patients with medical disorders known t...

The serial measurement of postoperative serum enzymes has been proposed as an important method for identifying myocardial infarction following aortocoronary graft surgery. Serum glutamic oxalacetic transaminase, creatine phosphokinase and lactic dehydrogenase levels were determined during the initial five days following direct coronary artery surgery in 112 patients. Enzyme test results were an...