conclusions detection and surveillance of the significant sites of mutations in hbv is crucial for clinicians to decide on the choice of antiviral treatment and further management of hepatitis b carriers. objectives this study was carried out to detect mutations in p gene of hepatitis b virus isolated from malaysian hbv carriers. materials and methods a total of 58 sera samples were analyzed by...

conclusions some il-10 promoter gene polymorphisms predisposed the infected hepatitis b virus cases to cirrhosis in our study population. patients and methods totally, 166 patients with chronic hepatitis b infection were enrolled. genotypes at different positions (i.e. -819, - 592, and - 1082) in the il-10 gene promoter were determined. results the c/a genotype at position -592, c/t genotype at...

Sergentomyia sintoni is the natural vector of Sauroleishmania species of lizards. This sandfly isabundance in and around the burrows of great gerbils. S. sintoni was collected from peridomestic animalshelters, inside and around houses and also from the nearby burrows of the gerbil reservoir hosts,Rhombomys opimus, in several provinces of Iran. Mitochondrial Cytochrome b (Cyt b) of sandflies, wh...

Abstract: iNOS is inducible by a variety of factors related to inflammation and referred to as inducible NOS(iNOS). It is regulated at the level of gene expression; once expressed, it produces NO at a high rate. iNOS gene-expression profiling is an important tool in understanding molecular markers of the responses of cells and tissues to external factors. In this article a semiquantitative reve...

Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL. Objective: This study was aimed to examine the ...

introduction: beta thalassemias are a heterogenous group of autosomal recessive disorders, characterized by reduced or absent production of the b-globin chain by the affected allele. transplantation of allogenic hematopoietic stem cells (hsc) is a curative approach but this therapeutic option is not available to the majority of patients. transplantation of genetically corrected autologous hsc i...

increased fetal hemoglobin (hbf) in b-globin gene disorders ameliorates the clinical symptoms of the underlying disease. 5-azacytidine, butyrate and hydroxyurea, have been shown to activate g-globin gene expression. it has also been found that hematopoietic growth factors can influence expression of g-globin in erythroid cultures and in animal models. this study was designed to evaluate the in ...

Background: Heterogeneous mutations in the human coagulation factor IX gene lead to an X-linked recessive bleeding disorder known as hemophilia B. The disease is distributed worldwide with no ethnic or geographical priority. Materials and Methods: The aim of this study was to characterize the factor IX gene mutations in 28 unrelated Iranian hemophilia B patients. Polymerase chain reaction (PCR)...