recent evidences suggest that multiple myeloma phenotypes (mmps) are involved in the infiltration of multiple myeloma-affected marrow foci. in this study, the effects of arsenic trioxide on the invasive and angiogenic phenotypes of multiple myeloma (mm) cell line were assessed on a dose-response and time-course basis. multiple myeloma cell line, karpas 707, was treated with step-wise elevated c...

we discuss here an uncommon condition of neurogenic hypotension in the context of immunoglobulin light chain (amyloid light-chain) amyloidosis. th e most serious feature was autonomic nervous system impairment, mainly characterized by severe refractory orthostatic hypotension, which became progressively invalidating, forcing the patient to bed. moreover, since the systemic involvement of the di...

In this Policy Review, the Bone Working Group of International Myeloma updates its clinical practice recommendations for management multiple myeloma-related bone disease. After assessing available literature and grading using Grading Recommendations, Assessment, Development, Evaluations (GRADE) method, experts from working group recommend zoledronic acid as preferred bone-targeted agent patient...

Immunotherapy is a rapidly developing field of multiple myeloma, disease which despite the development new drugs remains incurable. There are several antigens that being assessed in preclinical and clinical settings, but most studied all B-cell maturation antigen (BCMA). BCMA target for antibody conjugated with toxins (ADCs), bispecific engagers (BITEs), modified autologous lymphocytes (CAR-T, ...

Introduction: Multiple myeloma is a heterogeneous disease with different survival times among patients. Accurate prediction of prognosis in multiple myeloma is essential, as patients with a shorter survival time may require early bone marrow transplantation (BMT) and more advanced chemotherapy as a part of their first-line treatment. In the present study, a parameter, depicted by ga...

introduction: multiple myeloma is a neoplasm of monoclonal plasmacells which may cause oral manifestations. we report a 50-year-old man with a mass burned out of a post extraction socket. he had recived an eight month period of chemotherapy and was supposed to be ready for hematopoetic stem cell transplantation. after clinical and histopathological examinations, the mass was diagnosed as a plas...

second primary malignancy following multiple myeloma (mm) was reported several years ago. there are also rare reports of cases with synchronous mm and other malignancies. to our knowledge, only one case of mm following bladder cancer has been reported in the literature. here, we report the second case occurred three months after diagnosis of bladder cancer.

Multiple Myeloma (MM), a bone marrow plasma cell hematopoietic cancer, remains critical but incurable hematological malignancy, prone to deadly relapses even after existing treatment. In this review, I describe the origins of pro-tumor myeloma-associated macrophages. specifically outline how classically activated anti-tumor macrophages that home cancerous tumor microenvironment is polarized int...

introduction: plasmacytoma is a monoclonal proliferation of plasma cells. it can be an isolated lesion, for which the term extramedullary plasmacytoma is used, or a representation of multiple myeloma.the upper respiratory tract is the most common site for an extramedullary plasmacytoma. sinonasal plasmacytomas cause different symptoms depending on the sites of origins and the areas of involveme...