Introduction. Myeloid sarcomas (MS) are rare tumours occurring at extramedullary sites. They are usually associated with other haematology disorders such as acute myeloid leukaemia, myelodysplastic syndrome, and chronic myeloproliferative neoplasms. They frequently occur with a diagnosis of acute myeloid leukaemia (AML) or with relapse of preexisting disease. Patients with myeloid sarcomas with...

Chronic hypodipsic hypernatraemia in the absence of clinical hypovolaemia, with normal renal function is rare, and has been reported principally in patients with known hypothalamic lesions.1'2 Hypernatraemia has been found in acute myeloid leukaemia, but only in association with diabetes insipidus.3 This appears to be the first reported case of chronic hypodipsic hypernatraemia complicating acu...

We report a 44 year old man who developed external ophthalmoplegia and predominantly respiratory, truncal and bulbar weakness with brisk reflexes, histological evidence of an inflammatory myopathy and a high titre of acetylcholine receptor antibodies, one month after starting hydroxyurea and allopurinol for chronic myeloid leukaemia. The temporal relationship suggests a possible association bet...

The allogeneic bone marrow transplantation usually preceded by induction chemotherapy, in fit patients, represents the gold standard in the acute myeloid leukaemia. In the last years, many trials have been set up with the view of improving the number of remissions during the induction by adding new drugs. Several early or late side effects have been described in the literature. We herein presen...

IgA nephropathy is the most common primary glomerulonephritis, but the pathogenesis of IgA nephropathy is still unclear. A 32-year-old woman was found to have IgA nephropathy and acute myeloid leukaemia. She was treated with allogenic bone marrow transplantation (BMT). After BMT, immunoflourescent staining of IgA and proteinuria disappeared. These findings suggest bone marrow cells are involved...

In a cohort of 14 children with identical cardiac xenografts, two boys developed acute myeloid leukaemia 11 and 16 months respectively after the operation. A dedicated working group designed a scheme intending to take care of all aspects of the situation. This article focuses on preferred strategies towards patients, relatives, government, and the media. We did not find any substantial evidence...

Bone marrow fibre content was studied in 34 patients with acute myeloid leukaemia at presentation and subsequently after chemotherapy and at complete remission. The findings indicate that: some degree of marrow fibrosis is present in about one third of the patients with acute myeloid leukaemia at presentation; effective antileukaemia treatment may result in reversal of marrow fibrosis; and incr...

A patient with chronic myeloid leukaemia, having two unusual features, is described. He had absence of splenomegaly and marked periodic fluctuations of leucocyte counts, occurring spontaneously, in the initial phase of the disease. The latter finding suggests that, at least in some patients with chronic myeloid leukaemia, negative feed back control mechanism(s), possibly exerted by colony stimu...

Haematological neoplasms comprise a collection of heterogeneous neoplastic conditions that arise from cells the bone marrow and lymphoid system. This study describes pattern distribution haematological at tertiary hospital inNorthernProvince,Sri Lanka. A descriptive retrospective audit was conducted ofall diagnosed by peripheral blood examination. total 435 were reported during 4-year period. A...

Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to lack of efficacious targeted therapies. The Nuclear Factor Activated T Cells (NFAT) family transcription factors well characterised as regulator the cell cycle and differentiation in lineage. Recent evidence has demonstrated that NFAT members may have roles regulating AML leukemogenesis resistance therapy leukaem...